Oxycodone salt prepared according to the process of claim 1.

Oxycodone salt according to claim 30, wherein the oxycodone salt is oxycodone hydrochloride.

Oxycodone salt according to claim 31 having less than about 25 ppm 14-hydroxycodeinone.

Oxycodone salt according to claim 32 having less than about 15 ppm 14-hydroxycodeinone.

Oxycodone salt prepared according to the process of claim 57.

Oxycodone salt according to claim 76, wherein the oxycodone salt is oxycodone hydrochloride.

Oxycodone salt according to claim 77 having less than about 25 ppm 14-hydroxycodeinone.

Oxycodone salt according to claim 78 having less than about 15 ppm 14-hydroxycodeinone.

An oral dosage form comprising: (i) from about 5 mg to about 320 mg of oxycodone hydrochloride active pharmaceutical ingredient having less than 25 ppm 14-hydroxycodeinone, wherein at least a portion of the 14-hydroxycodeinone is derived from 8α,14-dihydroxy-7,8-dihydrocodeinone during conversion of oxycodone free base to oxycodone hydrochloride; and (ii) a pharmaceutically acceptable excipient. view more

The oral dosage form of claim 3, wherein the pharmaceutically acceptable excipient comprises a sustained release carrier.

An oxycodone hydrochloride active pharmaceutical ingredient having less than 25 ppm 14-hydroxycodeinone, wherein at least a portion of the 14:hydroxycodeinone is derived from 8α,14-dihydroxy-7,8-dihydrocodeinone.

The oxycodone hydrochloride active pharmaceutical ingredient of claim 1 having less than 15 ppm 14-hydroxycodeinone.

The oxycodone hydrochloride active pharmaceutical ingredient of claim 1 having less than 10 ppm 14-hydroxycodeinone.

A parenteral abuse-proofed solid dosage form for oral administration, comprising, in addition to one or more active ingredients with potential for abuse selected from the group consisting of opiates, opioids, tranquillizers, stimulants and narcotics, at least one viscosity-increasing agent in a quantity equal to or greater than 5 mg per dosage form and such that an aqueous extract obtained from the dosage form with 10 ml of water at 25° C. forms a gel which can still pass through a needle having a diameter of 0.9 mm and remains visually distinguishable when introduced by a needle into a further quantity of an aqueous liquid. view more

A dosage form according to claim 1, wherein the active ingredient is an opiate, opioid, tranquillizer or a narcotic selected from the group consisting of N-{1-[2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl]-4-methoxymethyl-4-piperidyl}propionanilide(alfentanil), 5,5-diallylbarbituric acid(allobarbital), allylprodine, alphaprodine, 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]-benzodiazepine(alprazolam), 2-diethylaminopropiophenone(amfepramone), (.+−.)-.alpha.-methylphenethylamine(amphetamine), 2-(.alpha.-methylphenet-hylamino)-2-phenylacetonitrile(amphetaminil), 5-ethyl-5-isopentylbarbituri- c acid(amobarbital), anileridine, apocodeine, 5,5-diethylbarbituric acid(barbital), benzylmorphine, bezitramide, 7-bromo-5-(2-pyridyl)-1H-1,4-benzodiazepine-2(3H)-one (bromazepam), 2-bromo-4-(2-chlorophenyl)-9-methyl-l-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine(brotizolam), 17-cyclopropylmethyl-4,5a-epoxy-7a[(S)-1-hydroxy-1,2,2-trimethyl-propyl]- -6-methoxy-6,14-endo-ethanomorphinan-3-ol(buprenorphine), 5-butyl-5-ethylbarbituric acid(butobarbital), butorphanol, (7-chloro-1,3-dihydro-1-methyl-2-oxo-5-phenyl-2H-1,4-benzodiazepin-3-yl)dimethylcarbamate(camazepam), (1S,2S)-2-amino-1-phenyl-1-propanol(cathine/D- -norpseudoephedrine), 7-chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-yl-amine 4-oxide(chlordiazepoxide), 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodi-azepine-2,4(3H,5H)-dione(clobazam), 5-(2-chlorophenyl)-7-nitro-1H-1,4-benz-odiazepin-2(3H)-one(clonazepam), clonitazene, 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid(clorazepate), 5-(2-chlorophenyl)-7-ethyl-1-methyl-1H-thieno[2,3-e][1,4]diazepin-2(3H)-one(clotiazepam), 10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydrooxazol-o [3,2-d][1,4]benzodiazepin-6 (5H)-one(cloxazolam), (−)-methyl-[3.beta.-benzoyloxy-2.beta.(1.alpha.H,5.alpha.H)-tropane carboxylate](cocaine), 4,5.alpha.-epoxy-3-methoxy-17-methyl-7-morphinen-6.alpha.-ol(codeine), 5-(1-cyclohexenyl)-5-ethyl barbituric acid(cyclobarbital), cyclorphan, cyprenorphine, 7-chloro-5-(2-chloropheny-l)-1H-1,4-benzodiazepin-2(3H)-one(delorazepam), desomorphine, dextromoramide, (+)-(1-benzyl-3-dimethylamino-2-methyl-1-phenylpropyl)pro-pionate(dextropropoxyphene), dezocine, diampromide, diamorphone, 7-chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one (diazepam), 4,5.alpha.-epoxy-3-methoxy-17-methyl-6.alpha.-morphinanol(dihydrocodeine)-, 4,5.alpha.-epoxy-17-methyl-3,6a-morphinandiol(dihydromorphine), dimenoxadol, dimephetamol, dimethylthiambutene, dioxaphetyl butyrate, dipipanone, (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol(dronabinol), eptazocine, 8-chloro-6-phenyl-4H-[1,2,4]-triazolo[4,3-(a)][1,4]benzodiazepine(estazolam), ethoheptazine, ethylmethylthiambutene, ethyl[7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-oxo-1H-1,4-benzodiazepine-3-carboxylate](ethyl loflazepate), 4,5.alpha.-epoxy-3-ethoxy-17-methyl-7-morphinen-6.alpha.-ol(ethylmorphine-), etonitazene, 4,5.alpha.-epoxy-7.alpha.-(1-hydroxy-1-methylbutyl)-6-meth-oxy-17-methyl-6,14-endo-etheno-morphinan-3-ol(etorphine), N-ethyl-3-phenyl-8,9,10-trinorbornan-2-ylamine (fencamfamine), 7-[2-(.alpha.-methylphenethylamino)ethyl]-theophylline)(fenethylline), 3-(.alpha.-methylphenethylamino)propionitrile(fenproporex), N-(1-phenethyl-4-piperidyl)propionanilide(fentanyl), 7-chloro-5-(2-fluorophenyl)-1-methyl-1H-1,4-benzodiazepin-2(3H)-one (fludiazepam), 5-(2-fluorophenyl)-1-methyl-7-nitro-1H-1,4-benzodiazepin-2(3H)-one(flunitrazepam), 7-chloro-1-(2-diethylaminoethyl)-5-(2-fluoropheny-l)-1H-1,4-benzodiazepin-2(3H)-one(flurazepam), 7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-1,4-benzodiazepin-2(3H)-one(halazepam), 10-bromo-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro[1,3]oxazolyl[3,2-d][1,-4]benzodiazepin-6(5H)-one (haloxazolam), heroin, 4,5.alpha.-epoxy-3-methox-y-17-methyl-6-morphinanone(hydrocodone), 4,5.alpha.-epoxy-3-hydroxy-17-methyl-6-morphinanone(hydromorphone), hydroxypethidine, isomethadone, hydroxymethylmorphinan, 11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-4H-[1,3]oxazino[3,2-d][1,4]benzodiazepine-4,7(6H)-dione(ketazolam), 1-[4-(3-hydroxyphenyl)-1-methyl-4-piperidyl]-1-propanone(ketobemidone), (3S,6S)-6-dimethylamino-4,4-diphenylheptan-3-yl acetate (levacetylmethadol(LAAM)), (−)-6-dimethylamino-4,4-diphenol-3-heptanone(l-evomethadone), (−)-17-methyl-3-morphinanol (levorphanol), levophenacylmorphane, lofentanil, 6-(2-chlorophenyl)-2-(4-methyl-1-pipera-zinylmethylene)-8-nitro-2H-imidazo[1,2-a][1,4]-benzodiazepin-1(4H)-one(lop-razolam), 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)- -one(lorazepam), 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1H-1,4-ben-zodiazepin-2(3H)-one(lormetazepam), 5-(4-chlorophenyl)-2,5-dihydro-3H-imid-azo[2,1-a]isoindol-5-ol (mazindol), 7-chloro-2,3-dihydro-1-methyl-5-phenyl- -1H-1,4-benzodiazepine(medazepam), N-(3-chloropropyl)-.alpha.-methylphenet-hylamine(mefenorex), meperidine, 2-methyl-2-propyltrimethylene dicarbamate(meprobamate), meptazinol, metazocine, methylmorphine, N,.alpha.-dimethylphenethylamine(metamphetamine), (.+−.)-6-dimethylamino-4,4-diphenol-3-heptanone(methadone), 2-methyl-3-o-tolyl-4(3H)-quinazolinon-e(methaqualone), methyl [2-phenyl-2-(2-piperidyl)acetate](methylphenidate)-, 5-ethyl-1-methyl-5-phenylbarbituric acid(methylphenobarbital), 3,3-diethyl-5-methyl-2,4-piperidinedione(methyprylon), metopon, 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-(midazolam), 2-(benzhydrylsulfinyl)acetamide(modafinil), 4,5.alpha.-epoxy-17-methyl-7-morphinen-3,6.alpha.-diol(morphine), myrophine, (.+−.)-trans-3-(1,1-dimethylheptyl)-7,8,10,10.alpha.-tetrahydr-o-1-hydroxy-6,6-dimethyl-6H-dibenzo-[b,d]pyran-9(6.alpha.H)-one(nabilone), nalbuphene, nalorphine, narceine, nicomorphine, 1-methyl-7-nitro-5-phenyl- -1H-1,4-benzodiazepin-2(3H)-one(nimetazepam), 7-nitro-5-phenyl-1H-1,4-benz-odiazepin-2(3H)-one(nitrazepam), 7-chloro-5-phenyl-1H-1,4-benzodiazepin-2(−3H)-one(nordazepam), norlevorphanol, 6-dimethylamino-4,4-diphenyl-3-hexano ne(normethadone), normorphine, norpipanone, the exudation from plants belonging to the species Papaver somniferum (opium), 7-chloro-3-hydroxy-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one(oxazepam), (cis-trans)-10-chloro-2,3,7,11b-tetrahydro-2-methyl-11b-phenyloxazolo[3,2- -d][1,4]benzodiazepin-6-(5H)-one(oxazolam), 4,5.alpha.-epoxy-14-hydroxy-3--methoxy-17-methyl-6-morphinanone(oxycodone), oxymorphone, plants and parts of plants belonging to the species Papaver somniferum (including the subspecies setigerum) (Papaver somniferum), papaveretum, 2-imino-5-phenyl-4-oxazolidinone(pernoline), 1,2,3,4,5,6-hexahydro-6,11-d- imethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocin-8-ol(pentazocine), 5-ethyl-5-(1-methylbutyl)-barbituric acid(pentobarbital), ethyl-(1-methyl-4-phenyl-4-piperidinecarboxylate)(pethidine), phenadoxone, phenomorphane, phenazocine, phenoperidine, piminodine, pholcodeine, 3-methyl-2-phenylmorpholine(phenmetrazine), 5-ethyl-5-phenylbarbituric acid(phenobarbital), .alpha., .alpha.-dimethylphenethylamine(phentermine), 7-chloro-5-phenyl-1-(2-propynyl)-1H-1,4-benzodiazepin-2(3H)-one(pinazepam), .alpha.-(2-piperidyl)benzhydryl alcohol(pipradrol), 1′-(3-cyano-3,3-diphenylpropyl)[1,4′-bipiperidine]-4′- -carboxamide(piritramide), 7-chloro-1-(cyclopropylmethyl)-5-phenyl-1H-1,4--benzodiazepin-2(3H)-one(prazepam), profadol, proheptazine, promedol, properidine, propoxyphene, N-(1-methyl -2-piperidinoethyl)-N-(2-pyridyl)p- ropionamide, methyl {3-[4-methoxycarbonyl-4-(N-phenylpropanamido)piperidin-o]propanoate}(remifentanil), 5-sec-butyl-5-ethylbarbituric acid (secbutabarbital), 5-allyl-5-(1-methylbutyl)-barbituric acid(secobarbital), N-{4-methoxymethyl-1-[2-(2-thienyl)ethyl]-4-piperidyl}propionanilide (sufentanil), 7-chloro-2-hydroxy-methyl-5-phenyl-1H-1,4-be-nzodiazepin-2(3H)-one(temazepam), 7-chloro-5-(1-cyclohexenyl)-1-methyl-1H--1,4-benzodiazepin-2(3H)-one(tetrazepam), ethyl (2-dimethylamino-1-phenyl-3- -cyclohexene-1-carboxylate)(tilidine (cis and trans)), tramadol, 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzod- iazepine(triazolam), 5-(1-methylbutyl)-5-vinylbarbituric acid(vinylbital), (1R*,2R*)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol, (1R,2R,4S)-2-(dimethylamino)methyl-4-(p-fluorobenzyloxy)-1-(m-methoxyphenyl)cyclohexanol and corresponding stereoisomeric compounds in each case and the corresponding derivatives thereof in each case, in particular esters or ethers, and the physiologically acceptable compounds thereof in each case, in particular salts and solvates. view more

A dosage form according to claim 1, comprising at least one active ingredient at least partially in controlled release form.

A dosage form according to claim 1, comprising the at least one viscosity-increasing agent in a quantity of ≧5 mg per administration unit.