A composition for topical application having penetration-enhancing properties consisting essentially of:</claim-text> a) an active agent, wherein said active agent is testosterone or derivatives thereof having a concentration of about 0.1% to about ) a penetration enhancing system consisting of (i) a membrane fluidizer comprising oleic acid; (ii) a C1-C4 alcohol; and (iii) a glycol; and c) a gelling agent, said composition having a pH value of between about 5 to about 8. view more

A composition in accordance with claim 1, wherein said active agent is testosterone.

A composition in accordance with claim 1, wherein said active agent is present from about 1% to about 2% weight to weight of said composition.

A composition in accordance with claim 5, wherein said oleic acid is present from about 0.1% to about 5% weight to weight of said composition.

A composition in accordance with claim 7, wherein said C<HIL><SB>1</SB></HIL>-C<HIL><SB>4 </SB></HIL>alcohol is a mixture of ethanol and isopropanol.

A composition in accordance with claim 15, wherein said glycol is propylene glycol.

A composition in accordance with claim 21, wherein said glycol is present from about 30% to about 40% weight to weight of said composition.

A composition for topical application having penetration-enhancing properties consisting essentially of:</claim-text> a) an active agent, wherein said active agent is testosterone or derivatives thereof having a concentration of about 0.1% to about ) a penetration-enhancing system consisting of (i) a membrane fluidizer comprising oleic acid; (ii) a C1-C4 alcohol; and (iii) a glycol; c) a gelling agent; and d) inert carriers, said composition having a pH value between about 5 to about 8. view more

A method for administering a topically or systemically active agent with increased penetration, said method comprising: topically administering to a mammal a composition comprising:</claim-text> a) testosterone or a derivative thereof having a ntration of about 0.1% to about 2%; b) a penetration-enhancing system comprising: (i) oleic acid; (ii) a C3 alcohol; and (iii) propylene glycol thereby administering a topically or systemically active agent with increased penetration. view more

A method in accordance with claim <HIL><BOLD>19</BOLD></HIL>, wherein testosterone or a derivative thereof is present in a concentration selected from the group consisting of 0.5%, 1.00%, 1.25%, 1.50% and 2.00% weight to weight of said composition.