A device comprising a passage; binding means in said device for binding a species substantially specifically, said binding means being in fluid communication with said passage; exposure means in said device for exposing said species to said binding means and for preventing said binding means from leaving said device; closed regeneration means for separating said species from said binding means for reuse of said binding means in said device; valving for selectively connecting said closed regeneration means in fluid communication with said binding means, and control means for automatically operating said valving. view more

The device of claim 13 wherein the closed regeneration means includes means for exposing said binding means to a reagent to release said species from said binding means.

The device of claim 13 wherein said closed regeneration means comprises a first container for a first reagent, and a valve selectively connecting said first container in fluid communication with said binding means to release said species from said binding means, said valve being controlled by said control means. view more

The device of claim 15 further including a species-collecting valve operated by said control means for withdrawing said separated species.

The device of claim 15 wherein the closed regeneration means comprises a second container for a second reagent, the second reagent being chosen to return said binding means to a regenerated condition, the control means selectively sequentially connecting said first container and said second container in fluid communication with said binding means. view more

A closed regeneration device for separating a molecule bound substantially specifically to a binding species for reuse of said binding species, said regeneration device comprising a first reagent, a first valve selectively connecting said first reagent in fluid communication with said molecule bound to the binding species to separate said molecule from said binding species, a second reagent, a second valve selectively connecting said second reagent in fluid communication with said binding species to return said binding species to a regenerated condition, and control means for automatically operating said valves. view more