Compositions and methods for enhanced gene expression in cone cells
First Claim
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1. A polynucleotide cassette for enhanced expression of a transgene in cone cells of a mammalian retina, comprising(a) a promoter region consisting of a truncated M-Opsin promoter having a sequence identity of 85% or more to SEQ ID NO:
- 80;
(b) a coding sequence operatively linked to the promoter region; and
(c) a polyadenylation site operatively linked to the coding sequence.
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Abstract
The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in cone cells.
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Citations
26 Claims
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1. A polynucleotide cassette for enhanced expression of a transgene in cone cells of a mammalian retina, comprising
(a) a promoter region consisting of a truncated M-Opsin promoter having a sequence identity of 85% or more to SEQ ID NO: - 80;
(b) a coding sequence operatively linked to the promoter region; and (c) a polyadenylation site operatively linked to the coding sequence. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
- 80;
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26. A polynucleotide cassette for enhanced expression of a transgene in cone cells of a mammalian retina, comprising SEQ ID NO:
- 95.
Specification