Composition of redox-reagents for electrochemical biosensor and biosensor comprising the same
First Claim
1. A composition of redox-reagent for use in an electrochemical biosensor, the composition comprising a redox enzyme and an electron transfer mediator,wherein the electron transfer mediator comprises:
- Ru(NH3)6Cl3; and
thionine, andwherein the redox enzyme is flavin adenine dinucleotide-glucose dehydrogenase.
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Accused Products
Abstract
A composition of redox-reagent containing metal-containing complex and thionine or its derivative as electron transfer mediator for use in an electrochemical biosensor, and a biosensor containing the same are provided. With the increase in reaction rate between redox enzyme-thionine (or its derivative)-metal-containing complex in the composition of redox-reagent containing metal-containing complex and thionine or its derivative, glucose detection efficiency markedly increases, and the composition is hardly influenced from high humidity and interfering substances. Accordingly, the composition of redox-reagent is useful in fabricating an electrochemical biosensor for detecting glucose in blood.
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Citations
19 Claims
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1. A composition of redox-reagent for use in an electrochemical biosensor, the composition comprising a redox enzyme and an electron transfer mediator,
wherein the electron transfer mediator comprises: -
Ru(NH3)6Cl3; and thionine, and wherein the redox enzyme is flavin adenine dinucleotide-glucose dehydrogenase. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A composition of redox-reagent for use in an electrochemical biosensor, the composition comprising a redox enzyme, an electron transfer mediator and a water-soluble polymer,
wherein the electron transfer mediator comprises: -
Ru(NH3)6Cl3; and thionine or 3-amino-7-(2,3,4,5,6-pentahydroxyhexanamido)-5-phenothiazinium, and wherein the redox enzyme is flavin adenine dinucleotide-glucose dehydrogenase. - View Dependent Claims (14)
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15. A composition of redox-reagent for use in an electrochemical biosensor comprising:
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a redox enzyme and an electron transfer mediator, wherein the electron transfer mediator comprises; a ruthenium complex; and 3-amino-7-(2,3,4,5,6-pentahydroxyhexanamido) 5-phenothiazinium. - View Dependent Claims (16, 17, 18, 19)
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Specification