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Polymerase-nucleic acid complex

  • US 10,000,798 B2
  • Filed: 10/07/2014
  • Issued: 06/19/2018
  • Est. Priority Date: 04/30/2004
  • Status: Active Grant
First Claim
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1. A polymerase-nucleic acid complex attached to a solid support, the polymerase-nucleic acid complex comprising:

  • a target nucleic acid, a polymerase comprising a nucleic acid binding cleft, and a topological tether, wherein the topological tether is attached to the polymerase through at least two anchors that straddle the nucleic acid binding cleft, whereby the topological tether entraps the target nucleic acid in the nucleic acid binding cleft of the polymerase, and wherein the polymerase-nucleic acid complex is attached to a solid support.

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