Systems, devices and methods for a hydroscopic based lateral flow assay
First Claim
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1. A device for detecting an analyte in a fluid sample, the device comprising:
- a strip comprising;
a sample receiving region configured to receive the fluid sample;
a capture region;
a non-capture region; and
a control region,wherein the strip is configured such that when the fluid sample is applied to the sample receiving region, the fluid sample flows laterally to the capture region, the non-capture region, and the control region;
a plurality of electrodes at least partially aligned with the capture region;
a plurality of electrodes at least partially aligned with the non-capture region;
a plurality of electrodes at least partially aligned with the control region; and
an electronic circuit comprising a processor coupled to the electrodes, the processor configured to execute a set of instructions to perform a method for detecting the analyte in the fluid sample, the method comprising;
measuring a drying-dependent impedance difference between the capture region and the non-capture region,measuring the drying-dependent impedance difference over a drying time period, wherein the drying time period comprises a length of time sufficient for the impedance difference to reach a maximum, andmeasuring impedances of the control region over the drying time period.
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Abstract
Systems, methods, and test kits for detecting and quantifying an analyte level in a biological fluid sample using impedance measurements, are disclosed. The fluid sample is applied to a lateral flow strip, and impedance of the strip is measured as the assay dries. Analysis of the drying-dependent impedance measurements indicates the presence and quantity of the analyte in the fluid sample.
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11 Claims
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1. A device for detecting an analyte in a fluid sample, the device comprising:
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a strip comprising; a sample receiving region configured to receive the fluid sample; a capture region; a non-capture region; and a control region, wherein the strip is configured such that when the fluid sample is applied to the sample receiving region, the fluid sample flows laterally to the capture region, the non-capture region, and the control region; a plurality of electrodes at least partially aligned with the capture region; a plurality of electrodes at least partially aligned with the non-capture region; a plurality of electrodes at least partially aligned with the control region; and an electronic circuit comprising a processor coupled to the electrodes, the processor configured to execute a set of instructions to perform a method for detecting the analyte in the fluid sample, the method comprising; measuring a drying-dependent impedance difference between the capture region and the non-capture region, measuring the drying-dependent impedance difference over a drying time period, wherein the drying time period comprises a length of time sufficient for the impedance difference to reach a maximum, and measuring impedances of the control region over the drying time period. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification