System and imaging method for using photoacoustic effect

• US 10,004,405 B2
• Filed: 05/26/2015
• Issued: 06/26/2018
• Est. Priority Date: 01/22/2015
• Status: Active Grant

• Current Assignee: National Taiwan University (Government of The Republic of China)
• Original Assignee: National Taiwan University (Government of The Republic of China)
• Inventors: Li, Pai-Chi, Chao, Pei-Yu, Wu, Kai-Wen
• Primary Examiner(s): Gillman, Amelie R
• Application Number:
  US14/721,096
• Publication Number:
  US 20160213256A1
• Time in Patent Office: 1,127 Days
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4483 characterised by features of the ultrasound transducer
• CPC Class Codes: G10K 15/046 using optical excitation, e.g. laser bundle

Abstract

A system and an imaging method for using photoacoustic effect are provided in the present invention. The system includes a light source for generating a light beam, a wave-guide probe and an ultrasound receiving device. The wave-guide probe further has a reception portion and at least one transmission portion. The reception portion receives the light beam and then triggers a photoacoustic effect inside the reception portion so as thereby to generate at least one sound wave thereinside to be further transmitted to the at least one transmission portion. The transmission portion is merged into the organic medium. When the sound wave is transmitted to the transmission portion, an ultrasound area is generated inside the organic medium. The ultrasound receiving device is located adjacent to the organic medium, receives the ultrasound generated in the ultrasound area to form an ultrasound image of the organic medium, so as to achieve the imaging method.

Claims

1. A system for using a photoacoustic effect to generate at least one ultrasound wave within an organic medium capable of acoustic coupling, the system comprising:

a light source for generating a light beam;

a longitudinally extended wave-guide probe consisting essentially of a material that generates the photoacoustic effect responsive to impingement by the light beam to thereby produce at least one sound wave, the wave-guide probe having;

a reception portion configured to be disposed external to the organic medium, the reception portion being impinged by the light beam to produce the at least one sound wave by the photoacoustic effect within the wave-guide probe at the reception portion; and

at least one transmission portion extended from the reception portion and configured to be at least partially disposed within the organic medium, the wave-guide probe thereby providing a unitary structure that both generates and transmits the at least one sound wave, wherein the at least one sound wave is propagated longitudinally from the reception portion to the at least one transmission portion to generate at least one ultrasound area inside the organic medium, to thereby produce at least one ultrasound wave in the at least one ultrasound area; and

an ultrasound receiver configured to be located adjacent to the organic medium to receive the at least one ultrasound wave.

2. The system for using a photoacoustic effect of claim 1, wherein the light beam is a laser beam.

3. The system for using a photoacoustic effect of claim 1, wherein the wave-guide probe is flexible.

4. The system for using photoacoustic effect of claim 1, wherein the material is metal and wherein the wave-guide probe further has an internal transmission pathway, and the internal transmission pathway is a through bore extending through the metal wave-guide probe for transmitting an agent to the at least one ultrasound area, and the agent is one of a curative agent, a nutritive agent and a diagnostic agent.

5. The system for using a photoacoustic effect of claim 1, wherein the at least one transmission portion comprises a plurality of transmission portions, the at least one ultrasound area comprises a plurality of ultrasound areas, the at least one ultrasound wave comprises a plurality of ultrasound waves, and a distance between the reception portion and each of the plurality of transmission portions is adjustably set to produce a focus point of the plurality of ultrasound waves inside the organic medium.

6. An imaging method comprising:

providing a light source for generating a light beam;

providing a longitudinally extended wave-guide probe consisting essentially of a material that generates a photoacoustic effect responsive to impingement by the light beam to thereby produce at least one sound wave, the wave-guide probe having a reception portion and at least one transmission portion spaced from the reception portion to define a unitary structure that both generates and transmits the at least one sound wave;

positioning the at least one transmission portion of the wave-guide probe at least partially within an organic medium, and the reception portion of the wave-guide probe being disposed external to the organic medium;

triggering the light source to transmit the light beam to impinge upon the reception portion of the wave-guide probe to produce the at least one sound wave by the photoacoustic effect within the wave-guide probe at the reception portion, and propagating the at least one sound wave longitudinally from the reception portion to the at least one transmission portion, and transmitting the at least one sound wave from the at least one transmission portion to generate at least one ultrasound area inside the organic medium to thereby produce at least one ultrasound wave in the at least one ultrasound area; and

applying an ultrasound receiver to receive the at least one ultrasound wave and forming an ultrasound image of the at least one ultrasound area.