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Microfluidic systems for electrochemical transdermal analyte sensing using a capillary-located electrode

  • US 10,004,434 B1
  • Filed: 03/15/2013
  • Issued: 06/26/2018
  • Est. Priority Date: 03/15/2013
  • Status: Active Grant
First Claim
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1. A sensing device comprising a plurality of individually controllable detection sites for electrochemically monitoring an analyte in interstitial fluid of a user, the device consisting of:

  • a hydrophobic layer, designed to contact the skin;

    an overlaying first structural layer;

    an overlaying metal electrode layer;

    an overlaying second structural layer;

    for each such detection site, a dual opening capillary channel traversing these layers, thus providing an opening adjacent the skin;

    wherein said metal electrode layer is discontinuous at the circumference of said capillary channel, such that two non-contiguous edge portions of the metal electrode layer are present within the circumference of said channel;

    a first non-contiguous edge portion of the metal electrode layer including a sensing layer applied thereto effective to measure the analyte, the sensing layer being exposed to an interior of the capillary channel;

    microheater surrounding a lower end of said capillary channel, adjacent said hydrophobic layer, the microheater being effective to produce heat when a sufficient voltage is applied thereto sufficient to ablate the stratum corneum of the underlying skin, such that interstitial fluid containing the analyte enters the capillary channel and contacts the first non-contiguous edge portion of the metal electrode layer including the sensing layer.

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