System for improved compressive tomography and method therefor

• US 10,004,464 B2
• Filed: 01/31/2014
• Issued: 06/26/2018
• Est. Priority Date: 01/31/2013
• Status: Active Grant

• Current Assignee: Duke University
• Original Assignee: Duke University
• Inventors: Brady, David Jones, Carin, Lawrence L., Kaganovsky, Yan
• Primary Examiner(s): SONG, HOON K
• Application Number:
  US14/764,435
• Publication Number:
  US 20150351705A1
• Time in Patent Office: 1,607 Days
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/4007 characterised by using a plurality of source units
• CPC Class Codes: A61B 6/4085 Cone-beams
• CPC Class Codes: A61B 6/4266 characterised by using a plurality of detector units A61B6/4014 takes precedence
• CPC Class Codes: A61B 6/52 Devices using data or image processing specially adapted for radiation diagnosis
• CPC Class Codes: G01N 2223/419 computed tomograph
• CPC Class Codes: G01N 2223/42 image digitised, -enhanced in an image processor
• CPC Class Codes: G01N 23/046 using tomography, e.g. computed tomography [CT]
• CPC Class Codes: G01V 5/226 using tomography
• CPC Class Codes: G06T 11/003 Reconstruction from projections, e.g. tomography
• CPC Class Codes: G06T 2207/10081 Computed x-ray tomography [CT]
• CPC Class Codes: G06T 7/0012 Biomedical image inspection

Abstract

A method and system for forming tomographic images of an object using discrete, non-continuous illumination rays is disclosed. In some embodiments, coded apertures, collimation filters, or reference structures are used to filter the set of illumination rays from a two- or three-dimensional radiation signal, wherein the set of illumination rays are then used to interrogate the object. In some embodiments, the object is interrogated with a set of illumination rays that is continuous and a sparse array of detectors is used to sub-sample the illumination rays after they have passed through the object.

Claims

1. A method for imaging an object, the method comprising:

performing a first measurement of a physical phantom with a continuous illumination pattern;

selecting a first set of illumination rays that are discrete and non-continuous, wherein the first set of illumination rays are selected based on the first measurement;

interrogating the object with the first set of illumination rays, wherein the first set of illumination rays are generated by operations comprising;

(i) generating a second set of illumination rays that is a continuous set of illumination rays; and

(ii) filtering the second set of illumination rays at a coded aperture to prevent at least one illumination ray of the second set thereof from interrogating the object;

generating a dataset that includes values for the attenuation of each illumination ray of the first set thereof, the attenuation being based on the structure of the object along the path of the illumination ray; and

reconstructing an image of the object based on the dataset.

2. The method of claim 1 wherein the first set of illumination rays includes illumination rays generated by a source at each of a plurality of source locations relative to the object.

3. The method of claim 2 wherein the plurality of source locations is determined randomly.

4. The method of claim 2 wherein the plurality of source locations are arranged uniformly about the object.

7. The method of claim 1 further comprising:

imparting a spatial code on scatter radiation received from the object, wherein the spatial code is imparted by passing the scatter radiation through a coded aperture that includes a first plurality of openings whose arrangement is defined by a first pattern code, wherein the scatter radiation is based on at least one illumination ray of the first set thereof;

detecting at least a portion of the encoded scatter information; and

estimating a material property of the object based on the detected encoded scatter information.

13. The method of claim 1 further comprising selecting a first aperture code for the coded aperture, wherein the first aperture code is based on the first measurement of the physical phantom.

14. The method of claim 13 further comprising:

performing a plurality of measurements of the physical phantom that includes the first measurement; and

determining a set of aperture codes suitable for use in the coded aperture, wherein each aperture code of the set thereof is based on a different measurement of the plurality thereof;

wherein the first aperture code is selected from the set of aperture codes.

5. A method for imaging an object, the method comprising:

performing a first measurement of a physical phantom with a continuous illumination pattern;

selecting a first set of illumination rays that are discrete and non-continuous, wherein the first set of illumination rays are selected based on the first measurement;

interrogating the object with the first set of illumination rays, wherein the first set of illumination rays are generated by operations comprising;

(i) interrogating the object with a second set of illumination rays that is a continuous set of illumination rays that includes the first set of illumination rays; and

(ii) subsampling the second set of illumination rays to select only the first set of illuminations rays for detection;

generating a dataset that includes values for the attenuation of each illumination ray of the first set thereof, the attenuation being based on the structure of the object along the path of the illumination ray; and

reconstructing an image of the object based on the dataset.

6. The method of claim 5 wherein the first set of illumination rays subsampled is selected randomly.

8. A system for forming an image of an object, the system comprising:

a source of radiation, the source being operative for providing a continuous illumination pattern;

a first coded aperture that converts the continuous illumination pattern into a first set of illumination rays that are discrete and non-continuous, wherein the first set of illumination rays are selected based on a first measurement of a physical phantom using the continuous illumination pattern, and wherein the first coded aperture includes a first plurality of openings arranged in a first pattern code that is dimensioned and arranged to convert the continuous illumination pattern into the first set of illumination rays;

a plurality of detectors, each detector of the plurality thereof being operative for detecting a different one of the first set of illumination rays; and

a processor that is operative for determining the attenuation of each of the set of illumination rays due to interaction with the object.

9. The system of claim 8 further comprising a stage operative for changing the relative orientation between the source and the object.

10. The system of claim 9, wherein the stage is further operative for randomly selecting each of a plurality of relative orientations between the source and object.

11. The system of claim 9, wherein the stage is further operative for positioning the source in each of a plurality of positions about the object, and wherein the plurality of positions are uniformly distributed about the object.

12. The system of claim 8 further comprising a second coded aperture that is operative for imparting a spatial code on scatter radiation received from the object, the second coded aperture including a second plurality of openings that pass scatter radiation such that it is substantially unchanged.

15. The method of claim 12 wherein the process is further operative for estimating a material property of the object based on the encoded scatter information.