Reserve zirconium phosphate module for use in sorbent dialysis

• US 10,004,838 B2
• Filed: 03/11/2015
• Issued: 06/26/2018
• Est. Priority Date: 06/24/2014
• Status: Active Grant

• Current Assignee: Mozarc Medical US LLC
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Gerber, Martin T., Hobot, Christopher M.
• Primary Examiner(s): Drodge, Joseph
• Application Number:
  US14/645,389
• Publication Number:
  US 20150367057A1
• Time in Patent Office: 1,203 Days
• Field of Search: 210 85, 210 961, 210 962, 210264, 2103216, 21032171, 210645, 210646, 210739, 210670, 210677, 210678, 210263, 210269, 604 501, 604 601, 604 609, 604 25, 604 65, 604 67, 436106, 436108, 436113, 502 20
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: B01D 61/30 Accessories; Auxiliary operation
• CPC Class Codes: B01D 61/32 Controlling or regulating
• CPC Class Codes: B01J 20/0211 Compounds of Ti, Zr, Hf
• CPC Class Codes: B01J 20/34 Regenerating or reactivating

Abstract

A reserve zirconium phosphate module for continuing dialysis in the event the capacity of the original zirconium phosphate module is exceeded. The sorbent cartridge can have a sensor for detecting when the capacity of the zirconium phosphate material has been exceeded, and a valve assembly for diverting the flow of spent dialysate into the reserve module when needed. Any of the modules of the sorbent cartridge can be reusable and the sorbent materials therein recharged.

Claims

1. A dialysate regeneration system comprising:

a material capable of converting urea to ammonia from a dialyzed fluid;

a first compartment having at least one sorbent material wherein the at least one sorbent material is capable of removing ammonia or ammonium ions generated from the converted urea from the dialyzed fluid;

a second compartment having at least one sorbent material capable of removing ammonia or ammonium ions generated from the converted urea from the dialyzed fluid;

at least one ammonia detector to detect ammonia breakthrough;

wherein one or more valves are responsive to detected ammonia breakthrough;

the first and second compartment in fluid communication with each other as controlled by the one or more valves positioned to selectively direct the fluid into one of the first and second compartments based on detection of ammonia breakthrough from the other one of the first and second compartments.

2. The dialysate regeneration system of claim 1, the at least one ammonia detector positioned in a fluid flow path wherein the ammonia detector detects ammonia or ammonium ions in the fluid after the fluid leaves the first or second compartment.

3. The dialysate regeneration system of claim 2, further comprising a processor configured to receive data from the ammonia detector;

wherein the processor automatically either;

(i) switches the one or more valves to direct flow into the second compartment based on the ammonia detector that detects ammonia or ammonium ions in a higher concentration than a pre-set value;

or

(ii) stops the dialysis system based on the ammonia detector that detects ammonia or ammonium ions in a higher concentration than a pre-set value and there is less than a pre-set amount of time remaining in a dialysis session.

4. The dialysate regeneration system of claim 2 wherein either:

(i) the at least one ammonia detector is positioned in the fluid flow path wherein the ammonia detector also detects ammonia or ammonium ions in the fluid after the fluid leaving the second compartment;

or

(ii) wherein the dialysate regeneration system further comprises a second ammonia detector positioned in a fluid flow path wherein the second ammonia detector detects ammonia or ammonium ions in the fluid leaving the second compartment.

5. The dialysate regeneration system of claim 1, further comprising one or more additional compartments positioned before or after the first compartment;

wherein the one or more additional compartments contain at least one sorbent material.

6. The dialysate regeneration system of claim 5, wherein any one of the additional compartments contains a sorbent material capable of converting urea into ammonia or ammonium ions.

7. The dialysate regeneration system of claim 6, further comprising a bypass line fluidly connected to a second set of one or more valves positioned before the additional compartment such that the fluid is caused to bypass the additional compartment;

wherein the second set of one or more valves automatically causes fluid to bypass the additional compartment based on that ammonia or ammonium ions are detected in a concentration higher than a pre-set value in the fluid leaving both the first compartment and the second compartment.

8. The dialysate regeneration system of claim 1, further comprising an alarm mechanism for providing an alert based on the ammonia detector detecting ammonia or ammonium ions in a higher concentration than a pre-set level.

9. The dialysate regeneration system of claim 1 wherein the at least one sorbent material in at least one of the first and second compartment comprises zirconium phosphate.

10. The dialysate regeneration system of claim 9 wherein the second compartment contains between 50 and 500 grams of zirconium phosphate, or between 100 and 1500 grams of zirconium phosphate.

11. The dialysate regeneration system of claim 1, further comprising a recharger fluidly connected to the one or more valves such that fluid is directed from the recharger into either or both of the first compartment and the second compartment.

12. The dialysate regeneration system of claim 1, further comprising a bypass line fluidly connected to the one or more valves such that the one or more valves direct the fluid into the bypass line to bypass either the first or second compartment.

13. The dialysate regeneration system of claim 1, wherein the one or more valves is a single valve positioned to direct the fluid into the second compartment and bypassing the first compartment based on the detection of ammonia breakthrough from one of the first and second compartments.

14. A dialysate regeneration system comprising:

a sorbent cartridge comprising at least a first compartment and a second compartment positioned in series;

the first compartment having at least one sorbent material wherein the at least one sorbent material is capable of removing ammonia or ammonium ions from a fluid;

the second compartment having at least one sorbent material capable of removing ammonia or ammonium ions from the fluid;

the first and second compartment in fluid communication with each other as controlled by one or more valves positioned on a connector after the first compartment;

a bypass line connected to the one or more valves positioned on a connector after the first compartment;

wherein the one or more valves are initially set to direct the fluid into the bypass line and around the second compartment and wherein the one or more valves are switched to direct the fluid into the second compartment based on detection of ammonia breakthrough from the first compartment; and

at least one ammonia detector to detect the ammonia breakthrough;

wherein the one or more valves are responsive to the detected ammonia breakthrough.

15. The dialysate regeneration system of claim 14, the at least one ammonia detector positioned in a fluid flow path after the first compartment such that the ammonia detector detects ammonia or ammonium ions in fluid leaving the first compartment.

16. The dialysate regeneration system of claim 15, further comprising a processor configured to receive data from the at least one ammonia detector;

wherein the processor causes the one or more valves to switch, such that the fluid is directed into the second compartment, when the ammonia detector detects ammonia or ammonium ions in the fluid leaving the first compartment.

17. The dialysate regeneration system of claim 14 wherein the first compartment further comprises a sorbent material capable of converting urea to ammonia or ammonium ions.

18. The dialysate regeneration system of claim 14, further comprising an additional compartment positioned before the first or second compartments wherein the additional compartment comprises at least one sorbent material capable of converting urea to ammonia or ammonium ions.

19. The dialysate regeneration system of claim 14, the one or more valves comprising a first set of valves and a second set of valves, wherein the first set of valves positioned to direct the fluid into the second compartment and the second set of valves positioned to direct the fluid bypassing the first compartment.

20. A method for performing dialysis, comprising:

determining an amount of ammonia leaving a first compartment capable of removing ammonia or ammonium ions generated from converting urea in a dialyzed fluid from a dialysis fluid using an ammonia sensor;

diverting flow of the dialysis fluid from the first compartment to a second compartment capable of removing ammonia or ammonium ions from a fluid based on detection of ammonia breakthrough from the first compartment by the ammonia sensor.

21. The method of claim 20, further comprising the step of:

switching one or more valves to direct the fluid into the second compartment when the ammonia detector detects ammonia or ammonium ions in the dialysis dialyzed fluid leaving the first compartment.

22. The method of claim 20, further comprising the step of:

bypassing the first compartment using the one or more valves such that the dialysis dialyzed fluid is directed into a bypass line and around the first compartment.