Injection device

• US 10,004,852 B2
• Filed: 04/08/2014
• Issued: 06/26/2018
• Est. Priority Date: 04/10/2013
• Status: Active Grant

• Current Assignee: Sanofi
• Original Assignee: Sanofi
• Inventors: Marsh, William, Morris, Anthony Paul, Butler, Joseph, Jones, Matthew
• Primary Examiner(s): Stiles, Amber
• Application Number:
  US14/783,121
• Publication Number:
  US 20160051766A1
• Time in Patent Office: 1,540 Days
• CPC Class Codes: A61M 2005/3125 specific display means, e.g. to indicate dose setting
• CPC Class Codes: A61M 2005/3126 Specific display means related to dosing
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31541 Means preventing setting of a dose beyond the amount remaining in the cartridge
• CPC Class Codes: A61M 5/3155 by rotational movement of dose setting member, e.g. during setting or filling of a syringe
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/31561 using freely adjustable volume steps
• CPC Class Codes: A61M 5/31568 Means keeping track of the total dose administered, e.g. since the cartridge was inserted
• CPC Class Codes: A61M 5/3157 Means providing feedback signals when administration is completed A61M5/20 takes precedence
• CPC Class Codes: A61M 5/31583 based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod

Abstract

The invention refers to a handheld injection device comprising a housing (10; 410), a dose indicator (90; 480) positioned within and axially constrained to the housing (10; 410) and rotatable with respect to the housing (10; 410) during dose setting and during dose dispensing, a gauge element (80; 490), which is at least partly interposed between the housing (10; 410) and the dose indicator (90; 480), wherein the gauge element (80; 490) is axially guided within the housing (10; 410) and in threaded engagement with the dose indicator (90; 480) such that rotation of the dose indicator (90; 480) causes an axial displacement of the gauge element (80; 490). A contrast element having a first marking is provided and at least a region of the gauge element (80; 490) is provided with a second marking, with the first marking and/or the second marking being visible through a first window (12a) or aperture in the housing (10; 410) depending on the axial position of the gauge element (80; 490) within the housing (10; 410).

Claims

1. An injection device comprising:

a housing;

a dose indicator positioned within and axially constrained to the housing and rotatable with respect to the housing during dose setting and during dose dispensing;

a gauge element at least partly interposed between the housing and the dose indicator, wherein the gauge element is axially guided within the housing and in threaded engagement with the dose indicator such that rotation of the dose indicator causes an axial displacement of the gauge element; and

a contrast element comprising a first marking, wherein at least a region of the gauge element comprises a second marking, wherein at least one of the first marking or the second marking is visible through a first window or a first aperture in the housing depending on the axial position of the gauge element within the housing, wherein the housing has a second aperture or second window and the gauge element has a third aperture or third window positioned with respect to the second aperture or second window of the housing such that at least a part of the dose indicator is visible through the second and third apertures or windows.

2. The injection device according to claim 1, wherein the contrast element is unitary with the housing or the dose indicator.

3. The injection device according to claim 1, wherein the gauge element does not protrude out of the housing during dose setting and during dose dispensing.

4. The injection device according to claim 1, further comprising a cartridge holder for receiving a cartridge, wherein the gauge element is guided in the housing such that the gauge element at least in one of its axial positions during dose setting overlaps at least a part of the cartridge.

5. The injection device according to claim 1, further comprising a resilient member adapted to provide a force necessary for ejecting a dose from the injection device.

6. The injection device according to claim 1, further comprising a piston rod, wherein the piston rod does not rotate during dose setting and rotates during dose dispensing.

7. The injection device according to claim 1, further comprising a drive member, wherein the drive member does not rotate during dose setting and rotates during dose dispensing.

8. The injection device according to claim 7, wherein the drive member is axially displaceable relative to the housing between a proximal dose setting position, wherein the drive member is rotationally constrained to the housing in the proximal dose setting position, and a distal dose dispensing position, wherein the drive member is rotationally decoupled from the housing in the distal dose dispensing position.

9. The injection device according to claim 7, further comprising a clutch arranged between the drive member and the dose indicator, wherein the clutch allows relative rotation of the drive member and the dose indicator during dose setting and rotationally constrains the drive member and the dose indicator during dose dispensing.

10. The injection device according to claim 1, further comprising a limiter mechanism defining a maximum settable dose and a minimum settable dose, the limiter mechanism comprising a first rotational stop on the dose indicator and a first counter stop on the gauge element, the first rotational stop and the first counter stop abutting in the minimum dose position, and a second rotational stop on the dose indicator and a second counter stop on the gauge element, the second rotational stop and the second counter stop abutting in the maximum dose position.

11. The injection device according to any of the claim 7, further comprising a last dose protection mechanism for preventing the setting of a dose which exceeds the amount of liquid left in a cartridge, wherein the last dose protection mechanism comprises a nut member located interposed between the drive member and the dose indicator or between a dial member and a clicker sleeve rotationally constrained to the housing.

12. The injection device according to claim 1, further comprising:

a first clicker producing at least one of an audible or tactile first feedback during at least one of dose setting or dose dispensing; and

a second clicker producing at least one of an audible or tactile second feedback, distinct from the first feedback, only during dose dispensing when the device reaches its minimum dose position.

13. The injection device according to claim 12, wherein the second clicker comprises a flexible arm provided on the dose indicator, wherein the flexible arm is displaceable in a radial direction by a flange or protrusion of the drive member or a clicker sleeve, and a radially inwardly protruding section of the gauge element, which passes over the flexible arm upon relative rotation of the dose indicator and the gauge element.

14. The injection device according to claim 1 further comprising a cartridge containing a medicament.

15. The injection device according to claim 1, further comprising a drive member that extends from an interface with the dose indicator to a splined tooth interface with the housing, wherein the splined tooth interface rotationally constrains the drive member during dose setting.

16. The injection device according to claim 15, further comprising a dial grip attached to an external surface of the housing, wherein pressing the dial grip disengages the drive member from the splined tooth interface allowing the drive member to rotate.

17. The injection device according to claim 15, further comprising a clutch plate, wherein the drive member extends from the interface with the dose indicator via the clutch plate.

18. The injection device according to claim 17, wherein the clutch plate comprises ratchet teeth that engage with teeth on a proximal end of the drive member.