Condenser systems for fluid processing systems

• US 10,005,005 B2
• Filed: 12/31/2014
• Issued: 06/26/2018
• Est. Priority Date: 03/21/2014
• Status: Active Grant

• Current Assignee: Life Technologies Corporation (Thermo Fisher Scientific Incorporated)
• Original Assignee: Life Technologies Corporation (Thermo Fisher Scientific Incorporated)
• Inventors: Brown, Jason D., Staheli, Clinton C., Meeks, Anthony D.
• Primary Examiner(s): Ketter, James S
• Application Number:
  US14/588,063
• Publication Number:
  US 20150265943A1
• Time in Patent Office: 1,273 Days
• Field of Search: None
• CPC Class Codes: B01D 5/00 Condensation of vapours; Recovering volatile solvents by condensation B01D8/00 takes precedence; condensers F28B
• CPC Class Codes: B01D 5/0015 Plates
• CPC Class Codes: B01D 53/002 by condensation
• CPC Class Codes: B01D 53/265 by refrigeration (condensation)
• CPC Class Codes: C12M 23/14 Bags
• CPC Class Codes: C12M 27/02 Stirrer or mobile mixing elements
• CPC Class Codes: C12M 29/06 Nozzles; Sprayers; Spargers; Diffusers per se B01F23/231, B01J19/26
• CPC Class Codes: C12M 29/26 Conditioning fluids entering or exiting the reaction vessel

Abstract

A condenser bag includes a body bounding a channel that extends between an inlet opening at a first end and an outlet opening and an opposing second end, the body being comprised of a polymeric film. An intake port is secured to the body at the inlet opening and bounds an port opening that extends therethrough and communicates with the channel. A tubular transfer line has a first end coupled with the body so as to communicate with the channel at a first location located between the inlet opening and the outlet opening and an opposing second end coupled with either the intake port so as to communicate with the port opening therein or with the body so as to communicate with the channel at a second location located between the intake port and the first location.

Claims

1. A condenser bag comprising:

a body bounding a channel that extends between an inlet opening at a first end and an outlet opening at an opposing second end, the body being comprised of a polymeric film; and

an intake port secured to the body at the inlet opening and bounding a port opening that extends therethrough and communicates with the channel; and

a tubular transfer line having a first end coupled with the body at a first location located between the inlet opening and the outlet opening so as to communicate with the channel and an opposing second end either coupled directly to the intake port so as to communicate with the port opening therein or coupled with the body at a second location located between the intake port and the first location so as to communicate with the channel.

2. The condenser bag as recited in claim 1, wherein the body comprises a collapsible polymeric bag.

3. The condenser bag as recited in claim 1, wherein the port opening of the intake port has a maximum transverse diameter that is greater than 4 cm.

4. The condenser bag as recited in claim 1, further comprising an exhaust port bounding a port opening, the exhaust port being coupled with the outlet opening of the body so that the port opening communicates with the channel of the body.

5. The condenser bag as recited in claim 1, wherein the body comprises a first leg connected to the intake port, a second leg, and an arm that extends between the first leg and the second leg, the first leg, second leg and arm forming a substantially U-shaped configuration with the channel passing therethrough, the second end of the transfer line being connected to the first leg of the body.

6. The condenser bag as recited in claim 5, wherein at least a portion of the first leg extends parallel to the second leg.

7. The condenser bag as recited in claim 5, wherein the body further comprises a third leg on which the outlet opening is formed, the portion of the channel bounded by and extended between the second leg and the third leg having a substantially U-shaped configuration.

8. The condenser bag as recited in claim 7, wherein the first end of the transfer line couples with the second leg or the third leg.

9. The condenser bag as recited in claim 7, wherein the body further comprises an extension projecting from the second leg or the third leg, the extension bounding a collection pocket that communicates with the channel, the first end of the transfer line coupling with the extension so as to communicate with the collection pocket.

10. The condenser bag as recited in claim 1, wherein the channel of the body is sterile.

11. A condenser system comprising:

the condenser bag as recited in claim 1; and

a pump coupled with the transfer line.

12. The condenser system as recited in claim 11, further comprising:

a condenser comprising a first panel and a second panel, the condenser bag being positioned between the first panel and the second panel; and

a chiller in fluid communication with the first panel and the second panel for cooling the temperature of the panels.

13. The condenser system as recited in claim 11, further comprising:

a first flexible bag comprised of a polymeric film coupled with the intake port of the condenser bag; and

a second flexible bag comprised of a polymeric film and coupled with the outlet opening of the condenser bag, a filter being at least partially disposed within the second flexible bag.

14. A system for mixing a liquid solution or suspension comprising:

(a) a container assembly comprising;

a collapsible bag bounding a compartment and having an upper end and an opposing lower end, the collapsible bag being comprised of a polymeric film and being adapted to hold a fluid;

a sparger disposed at the lower end of the collapsible bag for delivering a gas into the compartment of the collapsible bag;

an exhaust port secured to the upper end of the collapsible bag and bounding a port opening that extends therethrough and communicates with the compartment of the collapsible bag; and

(b) a condenser bag comprising;

a body bounding a channel that extends between an inlet opening at a first end and an outlet opening and an opposing second end, the body being comprised of a polymeric film; and

an intake port secured to the body at the inlet opening and bounding a port opening that extends therethrough and communicates with the channel, the intake port of the condenser bag being coupled with the exhaust port on the collapsible bag so that at least a portion of the body of the condenser bag is disposed at an elevation above the upper end of the collapsible bag.

15. The system as recited in claim 14, wherein the port opening of the intake port of the condenser bag and the port opening of the exhaust port of the collapsible bag each have a maximum diameter that is greater than 5 cm.

16. The system as recited in claim 14, wherein the intake port of the condenser bag is coupled directly to the exhaust port of the collapsible bag at the upper end of the collapsible bag.

17. The system as recited in claim 14, further comprising:

a support housing bounding a chamber in which the collapsible bag is supported;

a condenser coupled to the support housing so that at least a portion of the condenser is disposed at an elevation above the support housing, the condenser bag being supported by the condenser.

18. The system as recited in claim 14, further comprising:

the body of the condenser bag comprising a first end that is positioned above the intake port of the condenser bag so as to be disposed vertically above the upper end of the collapsible bag; and

a transfer line having a first end coupled with the body of the condenser bag so as to communicate with the channel at a first location located between the inlet opening and the outlet opening of the condenser bag and an opposing second end coupled with either the intake port of the condenser bag so as to communicate with the port opening thereof or with first end of the body of the condenser bag so as to communicate with the channel therein.

19. The system as recited in claim 14, further comprising a filter assembly coupled with the condenser bag, the filter assembly comprising:

a casing comprised of a polymeric film and bounding a compartment, the casing having an inlet opening communicating with the outlet opening of the body of the condenser filter bag and having a first outlet opening, at least a portion of the casing being disposed at an elevation above the condenser bag; and

a first filter at least partially disposed within the compartment of the casing so that gas passing through the compartment of the casing from the inlet opening to the first outlet opening must pass through the filter.

22. The system as recited in claim 14, wherein the at least a portion of the body of the condenser bag is disposed directly vertically above the upper end of the collapsible bag.

23. The system as recited in claim 18, wherein the second end of the tubular transfer line is coupled with the intake port or the first end of the body so that when a fluid is pumped through the tubular transfer line to the intake port or the body, the liquid falls under the force of gravity from the port opening or the channel into the compartment of the collapsible bag.

20. A method for processing a fluid, the method comprising:

sparging a fluid located within a compartment a container with a gas to form a humid gas;

passing the humid gas from the compartment of the container to a channel of a condenser bag, the condenser bag being comprised of a polymeric film and being at least partially disposed at an elevation above the container;

cooling the humid gas within the channel of the condenser bag so that at least a portion of the humid gas condenses into a liquid that collects within the condenser bag, thereby forming a dehumidified gas; and

pumping the liquid collected within the condenser bag to a first end of the channel of the condenser bag located above the container so that the liquid falls under the force of gravity from the channel into the compartment of the container.

21. The method as recited in claim 20, further comprising passing the dehumidified gas from the channel of the condenser bag to a compartment of a filter assembly, the filter assembly comprising:

a casing that is comprised of a polymeric film and that bounds the compartment, at least a portion of the casing being disposed at an elevation above the condenser bag; and

a first filter at least partially disposed within the compartment of the casing so that gas passing through the compartment of the casing must pass through the first filter.

24. A method for processing a fluid, the method comprising:

sparging a fluid located within a compartment a container with a gas to form a humid gas;

passing the humid gas from the compartment of the container to a channel of a condenser bag, the condenser bag being comprised of a polymeric film and being at least partially disposed at an elevation above the container;

cooling the humid gas within the channel of the condenser bag so that at least a portion of the humid gas condenses into a liquid that collects within the condenser bag, thereby forming a dehumidified gas; and

passing the dehumidified gas from the channel of the condenser bag to a compartment of a filter assembly, the filter assembly comprising;

a casing that is comprised of a polymeric film and that bounds the compartment, at least a portion of the casing being disposed at an elevation the condenser bag; and

a first filter at least partially disposed within the compartment of the casing so that gas passing through the compartment of the casing must pass through the first filter.