Hemodialysis and hemofiltration membranes based upon a two-dimensional membrane material and methods employing same
First Claim
1. A medical device comprising:
- an enclosure comprising a blood filtration membrane, wherein the blood filtration membrane comprises a perforated two-dimensional material comprising perforated graphene, the perforated two-dimensional material being disposed upon a porous support structure, andrenal tubule cells disposed within the enclosure;
wherein;
the perforated graphene is configured to retain the renal tubule cells; and
the perforated graphene is configured to allow selective entry and/or exit of at least one component contained in blood into and/or out of the enclosure.
2 Assignments
0 Petitions
Accused Products
Abstract
Perforated graphene and other perforated two-dimensional materials can be used in hemodialysis membranes and blood filtration membranes for selective removal of components from blood in vivo and ex vivo. The membranes are useful in hemodialysis and hemofiltration techniques to provide improved patient care. Hemodialysis systems can include a hemodialysis membrane formed from perforated graphene or another perforated two-dimensional material disposed upon a porous support structure. Hemofiltration systems can include one or more and preferably two or more blood filtration membrane formed from perforated graphene or another perforated two-dimensional material disposed upon a porous support structure. Methods for performing hemodialysis can involve exposing blood from a patient to a hemodialysis membrane formed from a perforated two-dimensional material. Ex vivo dialysis techniques can be performed similarly. Methods for filtration of blood can involve passing blood through one or more filter membranes or through a plurality of sequential filter membranes.
-
Citations
20 Claims
-
1. A medical device comprising:
-
an enclosure comprising a blood filtration membrane, wherein the blood filtration membrane comprises a perforated two-dimensional material comprising perforated graphene, the perforated two-dimensional material being disposed upon a porous support structure, and renal tubule cells disposed within the enclosure; wherein; the perforated graphene is configured to retain the renal tubule cells; and the perforated graphene is configured to allow selective entry and/or exit of at least one component contained in blood into and/or out of the enclosure. - View Dependent Claims (2, 3, 4, 9, 13, 14, 15, 16, 17)
-
-
5. A method comprising:
-
exposing blood to a blood filtration device, the blood filtration device comprising; an enclosure comprising a blood filtration membrane, wherein the blood filtration membrane comprises a perforated two-dimensional material comprising perforated graphene, the perforated two-dimensional material being disposed upon a porous support structure, and renal tubule cells disposed within the enclosure; wherein; the perforated graphene is configured to retain the renal tubule cells; and the perforated graphene is configured to allow selective entry and/or exit of at least one component contained in blood into and/or out of the enclosure. - View Dependent Claims (6, 7, 8, 10, 11, 12, 18, 19)
-
-
20. A blood filtration device comprising:
-
an enclosure comprising a blood filtration membrane, wherein the blood filtration membrane comprises at least one layer of a perforated two-dimensional graphene, the perforated two-dimensional material being disposed upon a porous support structure, and renal tubule cells disposed within the enclosure; wherein; the perforated graphene comprises apertures about 30 nm or less in size.
-
Specification