Facility and method for producing a container loaded with a biopharmaceutical fluid
First Claim
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1. Facility for the preparation of a container loaded with a biopharmaceutical fluid, wherein the facility comprises:
- a fluidtight container in which is placed a biopharmaceutical fluid and a gas which occupies an inner filling space, the container comprising a gas passage opening and being adapted to be filled with gas to an initial level of positive pressure in the inner filling space;
a control module for controlling the filling of the container with gas;
an analysis module for estimating a gas filling control parameter; and
a pumping means for generating a negative pressure in the inner filling space by forcing the gas to flow out of the container via the gas passage opening, the control module and the pumping means being coordinated to adjust the duration of the forced flow on the basis of the control parameter determined by the analysis module.
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Abstract
A facility (1) for producing a container loaded with a biopharmaceutical fluid, includes: a container (2) wherein a biopharmaceutical fluid is placed (B); a control module (9) for controlling the filling of gas into the container (2); and an analysis module (10) for estimating a parameter for controlling the gas filling; and a pumping device (40) for generating a depression in the inner filling space (Vg).
29 Citations
19 Claims
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1. Facility for the preparation of a container loaded with a biopharmaceutical fluid, wherein the facility comprises:
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a fluidtight container in which is placed a biopharmaceutical fluid and a gas which occupies an inner filling space, the container comprising a gas passage opening and being adapted to be filled with gas to an initial level of positive pressure in the inner filling space; a control module for controlling the filling of the container with gas; an analysis module for estimating a gas filling control parameter; and a pumping means for generating a negative pressure in the inner filling space by forcing the gas to flow out of the container via the gas passage opening, the control module and the pumping means being coordinated to adjust the duration of the forced flow on the basis of the control parameter determined by the analysis module. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. Method for preparing a sealed container loaded with a biopharmaceutical fluid, a gas occupying an inner filling space inside the container at an initial level of positive pressure, wherein the gas filling level within the container is controlled, the method comprising the steps of:
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b) estimating a gas filling control parameter which is representative of said inner filling space, c) generating a negative pressure in the inner filling space by forcing gas to flow out of the container, the duration of the forced flow being adjusted according to said control parameter. - View Dependent Claims (14, 15, 16, 17, 18, 19)
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Specification