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Facility and method for producing a container loaded with a biopharmaceutical fluid

  • US 10,005,575 B2
  • Filed: 03/20/2014
  • Issued: 06/26/2018
  • Est. Priority Date: 03/22/2013
  • Status: Active Grant
First Claim
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1. Facility for the preparation of a container loaded with a biopharmaceutical fluid, wherein the facility comprises:

  • a fluidtight container in which is placed a biopharmaceutical fluid and a gas which occupies an inner filling space, the container comprising a gas passage opening and being adapted to be filled with gas to an initial level of positive pressure in the inner filling space;

    a control module for controlling the filling of the container with gas;

    an analysis module for estimating a gas filling control parameter; and

    a pumping means for generating a negative pressure in the inner filling space by forcing the gas to flow out of the container via the gas passage opening, the control module and the pumping means being coordinated to adjust the duration of the forced flow on the basis of the control parameter determined by the analysis module.

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