β-D-2′-deoxy-2′-α-fluoro-2′β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment

• US 10,005,811 B2
• Filed: 10/12/2017
• Issued: 06/26/2018
• Est. Priority Date: 03/06/2015
• Status: Active Grant

• Current Assignee: Atea Pharmaceuticals, Inc.
• Original Assignee: Atea Pharmaceuticals, Inc.
• Inventors: Sommadossi, Jean-Pierre, Moussa, Adel
• Primary Examiner(s): McIntosh, III, Traviss C
• Application Number:
  US15/782,638
• Publication Number:
  US 20180030082A1
• Time in Patent Office: 257 Days
• Field of Search: None
• CPC Class Codes: A61K 31/7076 containing purines, e.g. adenosine, adenylic acid
• CPC Class Codes: A61P 31/14 for RNA viruses
• CPC Class Codes: C07H 19/16 Purine radicals
• CPC Class Codes: C07H 19/20 with the saccharide radical esterified by phosphoric or polyphosphoric acids
• CPC Class Codes: C07H 19/207 the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide

Abstract

A compound of the structure:

or a pharmaceutically acceptable salt or composition thereof for the treatment of a host infected with or exposed to an HCV virus or other disorders more fully described herein.

Claims

1. A compound of Formula:

2. The compound of claim 1, wherein the stabilized phosphate prodrug is a phosphoramidate.

3. The compound of claim 2, wherein the phosphoramidate is

4. The compound of claim 3, wherein R^P1 is aryl.

5. The compound of claim 4, wherein R^P1 is phenyl.

6. The compound of claim 3,

wherein

R¹⁶ is hydrogen;

R¹⁷ is (C₁-C₈)alkyl;

R¹⁸ is hydrogen; and

R¹⁹ is (C₁-C₆)alkyl.

7. The compound of claim 6, wherein R^P1 is aryl.

8. The compound of claim 7, wherein R^P1 is phenyl.

9. The compound of claim 3, wherein the phosphoramidate is

10. The compound of claim 3, wherein the phosphoramidate is

11. The compound of claim 3, wherein the phosphoramidate is

12. The compound of claim 1 of the formula:

13. The compound of claim 12 of the formula:

14. The compound of claim 1 of the formula:

15. The compound of claim 14 of the formula:

16. The compound of claim 1 of the formula:

17. The compound of claim 16 of the formula:

18. The compound of claim 1 of the formula:

19. The compound of claim 18 of the formula:

20. A compound of the formula:

21. The compound of claim 20 of the formula:

22. The compound of claim 20 of the formula: