System and method for multi-parameter spectroscopy

• US 10,006,859 B2
• Filed: 01/13/2017
• Issued: 06/26/2018
• Est. Priority Date: 07/24/2014
• Status: Active Grant

• Current Assignee: Nxgen Partners Ip, LLC (NxGen Partners LLC)
• Original Assignee: Nxgen Partners Ip, LLC (NxGen Partners LLC)
• Inventors: Ashrafi, Solyman
• Primary Examiner(s): Ahmed, Jamil
• Application Number:
  US15/405,974
• Publication Number:
  US 20170138851A1
• Time in Patent Office: 529 Days
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: G01N 21/21 Polarisation-affecting properties G01N21/19 takes precedence
• CPC Class Codes: G01N 21/3581 using far infrared light; using Terahertz radiation
• CPC Class Codes: G01N 21/59 Transmissivity G01N21/25 takes precedence
• CPC Class Codes: G01N 21/6486 Measuring fluorescence of biological material, e.g. DNA, RNA, cells G01N21/6428 takes precedence
• CPC Class Codes: G01N 21/65 Raman scattering
• CPC Class Codes: G01N 2333/4709 Amyloid plaque core protein
• CPC Class Codes: G01N 2800/2821 Alzheimer
• CPC Class Codes: G01N 33/483 Physical analysis of biological material
• CPC Class Codes: G01N 33/487 of liquid biological material
• CPC Class Codes: G01N 33/6896 Neurological disorders, e.g. Alzheimer's disease

Abstract

An apparatus for detecting a material within a sample includes a light emitting unit for directing at least one light beam through the sample. A plurality of units receive the light beam that has passed through the sample and performs a spectroscopic analysis of the sample based on the received light beam. Each of the plurality of units analyze a different parameter with respect to the sample a provide a separate output signal with respect to the analysis. A processor detects the material with respect each of the provided separate output signals.

Claims

1. An apparatus for detecting a material within a sample, comprising:

a light emitting unit for directing at least one light beam having an orbital angular momentum applied thereto through the sample, the at least one light beam having a unique vibrational and rotational signature combination associated therewith responsive to passing through the sample;

an OAM spectroscopic unit for receiving the at least one light beam that has passed though the sample and performing an orbital angular momentum (OAM) spectroscopic analysis to detect a rotational signature associated with the sample;

an infrared spectroscopic unit for receiving the at least one light beam that has passed through the sample and performing an infrared spectroscopic analysis to detect a vibrational signature associated with the sample, wherein the vibrational signature relates to molecular vibrations caused by the material within the sample;

a database including a plurality of unique combinations of vibrational and rotational signatures, each of the plurality of unique combinations of vibrational and rotational signatures associated with a particular material; and

a processor for detecting the material within the sample responsive to a comparison of the unique combination of the vibrational and the rotational signatures detected by the OAM spectroscopic unit and the infrared spectroscopic unit with the plurality of unique combinations of vibrational and rotational signatures within the database and a determination of a matching unique combination of vibrational and rotational signatures within the database, wherein the identification of the unique combination of vibration and rotational signatures enables detection of the material not detectable using either the vibrational signature or the rotational signature alone.

2. The apparatus of claim 1 further comprising:

a Raman spectroscopic unit for receiving the at least one light beam that has passed through the sample and performing a Raman spectroscopic analysis to detect a second vibrational signature associated with the sample, wherein the second vibrational signature relates to molecular vibrations caused by the material within the sample;

wherein the database further includes a plurality of unique combinations of vibrational, second vibrational and rotational signatures, each of the plurality of unique combinations of vibrational, second vibrational and rotational signatures associated with a particular material; and

wherein the processor further detects the material within the sample responsive to a comparison of the unique combination of the vibrational, the second vibrational and the rotational signatures detected by the infrared spectroscopic unit, the OAM spectroscopic unit and the Raman spectroscopic unit with the plurality of unique combinations of vibrational, second vibrational and rotational signatures within the database and a determination of a matching unique combination of vibration, second vibrational and rotational signatures within the database, wherein the identification of the unique combination of vibrational, second vibrational and rotational signatures enables detection of the material not detectable using either the vibrational signature, the second vibrational signal or the rotational signature alone.

3. An apparatus for detecting a material within a sample, comprising:

a light emitting unit for directing at least one light beam having an orbital angular momentum applied thereto through the sample, the at least one light beam having a unique vibrational and rotational signature combination associated therewith responsive to passing through the sample;

an OAM spectroscopic unit for receiving the at least one light beam that has passed though the sample and performing an orbital angular momentum (OAM) spectroscopic analysis to detect a rotational signature associated with the sample;

a fluorescence spectroscopic unit for receiving the at least one light beam that has passed through the sample and performing an fluorescence spectroscopic analysis to detect a vibrational energy level associated with the sample, wherein the vibrational energy level relates to molecular vibrations caused by the material within the sample;

a database including a plurality of unique combinations of vibrational energy levels and rotational signatures, each of the plurality of unique combinations of vibrational energy levels and rotational signatures defining a unique spectral map associated with a particular material; and

a processor for detecting the material within the sample responsive to a comparison of the unique combination of the vibrational energy level and the rotational signature detected by the fluorescence spectroscopic unit and the OAM spectroscopic unit with the plurality of unique combinations of vibrational energy levels and rotational signatures within the database and a determination of a matching unique spectral map within the database, wherein the identification of the matching unique spectral map enables detection of the material not detectable using either the vibrational energy level or the rotational signature alone.

4. The apparatus of claim 3, wherein the fluorescence spectroscopic analysis holds an exciting radiation at a fixed wavelength and measures the emitted fluorescence intensity as a function of emission wavelength.

5. An apparatus for detecting a material within a sample, comprising:

a light emitting unit for directing at least one light beam having an orbital angular momentum applied thereto through the sample, the at least one light beam having a unique vibrational and rotational signature combination associated therewith responsive to passing through the sample;

an OAM spectroscopic unit for receiving the at least one light beam that has passed though the sample and performing an orbital angular momentum (OAM) spectroscopic analysis to detect a rotational signature associated with the sample;

a Raman spectroscopic unit for receiving the at least one light beam that has passed through the sample and performing a Raman spectroscopic analysis to detect a vibrational signature associated with the sample, wherein the vibrational signature relates to molecular vibrations caused by the material within the sample;

a database including a plurality of unique combinations of vibrational and rotational signatures, each of the plurality of unique combinations of vibrational and rotational signatures associated with a particular material; and

a processor for detecting the material within the sample responsive to a comparison of the unique combination of the vibrational and rotational signatures detected by the OAM spectroscopic unit and the Raman spectroscopic unit with the plurality of unique combinations of vibrational and rotational signatures within the database and a determination of a matching unique combination of vibrational and rotational signatures within the database, wherein the identification of the unique combination of vibration and rotational signatures enables detection of the material not detectable using either the vibrational signature or the rotational signature alone.

6. An apparatus for detecting a material within a sample, comprising:

a light emitting unit for directing at least one light beam having an orbital angular momentum applied thereto through the sample, the at least one light beam having a unique vibrational and rotational signature combination associated therewith responsive to passing through the sample;

an OAM spectroscopic unit for receiving the at least one light beam that has passed though the sample and performing an orbital angular momentum (OAM) spectroscopic analysis to detect a rotational signature associated with the sample;

a terahertz spectroscopic unit for receiving the at least one light beam that has passed through the sample and performing a terahertz spectroscopic analysis to detect a vibrational signature associated with the sample within a far-infrared frequency range, wherein the vibrational signature relates to molecular vibrations caused by the material within the sample;

a database including a plurality of unique combinations of vibrational and rotational signatures, each of the plurality of unique combinations of vibrational and rotational signatures associated with a particular material; and

a processor for detecting the material within the sample responsive to a comparison of the unique combination of the vibrational and the rotational signatures detected by the OAM spectroscopic unit and the terahertz spectroscopic unit with the plurality of unique combinations of vibrational and rotational signatures within the database and a determination of a matching unique combination of vibration and rotational signatures within the database, wherein the identification of the unique combination of vibrational and rotational signatures enables detection of the material not detectable using either the vibrational signature or the rotational signature alone.

7. The apparatus of claim 6, wherein the terahertz spectroscopic unit provides terahertz spectroscopic analysis that selectively detects weak inter-molecular and weak intra-molecular vibrational modes that may not be detected by infrared spectroscopy.

8. The apparatus of claim 6, wherein the terahertz spectroscopic unit provides terahertz spectroscopic analysis that selectively detects two dimensional THz absorption properties.

9. The apparatus of claim 6, wherein the terahertz spectroscopic unit provides terahertz spectroscopic analysis that scans the sample in two dimensions a plurality of times, each of the scans being scaled with a different sample size.