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Biosensing system and methods using electron-ionic mechanisms at fluid-sensor interfaces

  • US 10,006,882 B2
  • Filed: 11/20/2015
  • Issued: 06/26/2018
  • Est. Priority Date: 11/21/2014
  • Status: Active Grant
First Claim
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1. A biosensor, comprising:

  • a semiconductor sensing element;

    a first conducting electrode and a second conducting electrode located on a first plane of the sensing element, wherein a first electric field is applied across the first electrode and the second electrode;

    a third conducting electrode located on a second plane of the sensing element parallel to and removed from the first plane, wherein a second electric field is applied across the first electrode and the third electrode perpendicular to the first electric field; and

    a dielectric substrate having a first portion adjacent a second portion, the first portion adjacent the sensing element and comprising pores, the first portion facilitating reception and containment of a fluid comprising an analyte on a surface of the sensing element distal from the third electrode, the surface defining an interface between the first portion and the sensing element, and the second portion facilitating dielectric separation of the fluid from the first electrode, the second electrode and the third electrode, wherein the mutually perpendicular first electric field and the second electric field facilitate adjusting a height of a fluid-sensor interface comprising an electrical double layer (EDL) in the fluid enabling detection and characterization of the analyte;

    wherein the first portion of the substrate facilitates reception and containment of the fluid in the pores.

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