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Nanopore biosensors for detection of proteins and nucleic acids

  • US 10,006,905 B2
  • Filed: 03/25/2014
  • Issued: 06/26/2018
  • Est. Priority Date: 03/25/2013
  • Status: Active Grant
First Claim
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1. A modified ClyA pore comprising a plurality of subunits, wherein each subunit comprises a polypeptide represented by an amino acid sequence of at least 80% identical to SEQ ID NO:

  • 1 and wherein (a) exactly one Cys residue is substituted with Ala;

    (b) exactly one Cys residue is substituted with Ser and exactly one Cys residue is substituted with Ala;

    or (c) exactly one Cys residue is substituted with Ser and one or more of L99, E103, F166, and K294 are substituted with other amino acid residues, wherein the positions of the amino acid substitutions are numbered with reference to an amino acid sequence as set forth in SEQ ID NO;

    1 starting from the third amino acid residue.

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