Systems and methods for estimating ischemia and blood flow characteristics from vessel geometry and physiology
First Claim
1. A method for determining fractional flow reserve (FFR) for a stenosis of interest for a patient, comprising:
- receiving medical image data of the patient including the stenosis of interest;
extracting a set of anatomical and/or geometric features for the stenosis of interest from the medical image data of the patient;
receiving a set of training data comprising;
(1) measured FFR values and (2) anatomical and/or geometric features, of a plurality of individuals;
training a machine learning algorithm based on determined associations mapping the measured FFR values and the anatomical and/or geometric features, for each of the plurality of individuals;
determining a FFR value for the stenosis of interest based on the extracted set of anatomical and/or geometric features using the trained machine-learning algorithm mapping anatomical and/or geometric features to FFR values; and
generating and displaying a geometric model of at least the stenosis of interest of the patient, and indicating the determined FFR value for the stenosis of interest in the geometric model.
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Accused Products
Abstract
Systems and methods are disclosed for determining individual-specific blood flow characteristics. One method includes acquiring, for each of a plurality of individuals, individual-specific anatomic data and blood flow characteristics of at least part of the individual'"'"'s vascular system; executing a machine learning algorithm on the individual-specific anatomic data and blood flow characteristics for each of the plurality of individuals; relating, based on the executed machine learning algorithm, each individual'"'"'s individual-specific anatomic data to functional estimates of blood flow characteristics; acquiring, for an individual and individual-specific anatomic data of at least part of the individual'"'"'s vascular system; and for at least one point in the individual'"'"'s individual-specific anatomic data, determining a blood flow characteristic of the individual, using relations from the step of relating individual-specific anatomic data to functional estimates of blood flow characteristics.
51 Citations
19 Claims
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1. A method for determining fractional flow reserve (FFR) for a stenosis of interest for a patient, comprising:
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receiving medical image data of the patient including the stenosis of interest; extracting a set of anatomical and/or geometric features for the stenosis of interest from the medical image data of the patient; receiving a set of training data comprising;
(1) measured FFR values and (2) anatomical and/or geometric features, of a plurality of individuals;training a machine learning algorithm based on determined associations mapping the measured FFR values and the anatomical and/or geometric features, for each of the plurality of individuals; determining a FFR value for the stenosis of interest based on the extracted set of anatomical and/or geometric features using the trained machine-learning algorithm mapping anatomical and/or geometric features to FFR values; and generating and displaying a geometric model of at least the stenosis of interest of the patient, and indicating the determined FFR value for the stenosis of interest in the geometric model. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A system for determining fractional flow reserve (FFR) for a stenosis of interest for a patient, the system comprising:
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a digital storage device storing instructions that, when executed by a processor, cause the computer system to perform a method for determining FFR for the stenosis of interest for the patient; and
a processor configured to execute the instructions to perform the method for determining FFR for the stenosis of interest for the patient, the method comprising;receiving medical image data of the patient including the stenosis of interest; extracting a set of anatomical and/or geometric features for the stenosis of interest from the medical image data of the patient; receiving a set of training data comprising;
(1) measured FFR values and (2) anatomical and/or geometric features, of a plurality of individuals;training a machine learning algorithm based on determined associations mapping the measured FFR values and the anatomical and/or geometric features, for each of the plurality of individuals; determining a FFR value for the stenosis of interest based on the extracted set of anatomical and/or geometric features using the trained machine-learning algorithm mapping anatomical and/or geometric features to FFR values; and generating and displaying a geometric model of at least the stenosis of interest of the patient, and indicating the determined FFR value for the stenosis of interest in the geometric model. - View Dependent Claims (16, 17, 18)
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19. A non-transitory computer readable medium storing computer program instructions for determining fractional flow reserve (FFR) for a stenosis of interest for a patient, the computer program instructions when executed on a processor cause the processor to perform operations comprising:
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receiving medical image data of the patient including the stenosis of interest; extracting a set of anatomical and/or geometric features for the stenosis of interest from the medical image data of the patient; receiving a set of training data comprising;
(1) measured FFR values and (2) anatomical and/or geometric features, of a plurality of individuals;training a machine learning algorithm based on determined associations mapping the measured FFR values and the anatomical and/or geometric features, for each of the plurality of individuals; determining a FFR value for the stenosis of interest based on the extracted set of anatomical and/or geometric features using the trained machine-learning algorithm mapping anatomical and/or geometric features to FFR values; and generating and displaying a geometric model of at least the stenosis of interest of the patient, and indicating the determined FFR value for the stenosis of interest in the geometric model.
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Specification