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Systems, devices and methods for in situ calibration of implantable sensors

  • US 10,010,274 B2
  • Filed: 12/17/2012
  • Issued: 07/03/2018
  • Est. Priority Date: 12/16/2011
  • Status: Active Grant
First Claim
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1. A system for monitoring the concentration of an analyte, comprising:

  • a housing configured to be disposed on a patient'"'"'s skin surface, the housing comprising;

    a reservoir configured to hold a glucose calibration fluid, the glucose calibration fluid having a known concentration of glucose included therein, the reservoir being in fluid connection with a conduit through which the glucose calibration fluid is delivered from the reservoir to an implant site positioned at a depth under the patient'"'"'s skin surface; and

    a sensor assembly comprising a glucose sensor, the glucose sensor being configured to extend from the housing to the implant site when the housing is disposed on the patient'"'"'s skin surface, said glucose sensor being configured to obtain measurements of concentration level of glucose present in a subcutaneous interstitial fluid at the implant site at a plurality of points in time before and after delivery of the calibration fluid to the implant site; and

    a calibration system configured to calibrate the glucose sensor in situ using the measurements of the concentration level of glucose in the subcutaneous interstitial fluid following delivery of the glucose calibration fluid to the implant site.

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