Endovascular occlusion device with hemodynamically enhanced sealing and anchoring

• US 10,010,328 B2
• Filed: 10/09/2015
• Issued: 07/03/2018
• Est. Priority Date: 07/31/2013
• Status: Active Grant

• Current Assignee: Embolic Acceleration, LLC
• Original Assignee: Neuvt Limited
• Inventors: Cragg, Andrew H., Logan, John, Naglreiter, Brett E., Espinosa, Alejandro
• Primary Examiner(s): Anderson, Gregory
• Assistant Examiner(s): Lauer, Christina
• Application Number:
  US14/880,126
• Publication Number:
  US 20160030052A1
• Time in Patent Office: 998 Days
• CPC Class Codes: A61B 17/12031 complete occlusion
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12177 comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61B 2017/22082 after introduction of a substance

Abstract

A vascular occlusion device having an expandable frame that carries a membrane. The membrane can include a tubular portion configured to transition between an open configuration in which the tubular portion is configured to receive a guidewire and a closed configuration in which the tubular portion is configured to occlude blood flow.

Claims

1. A vascular occlusion device, comprising:

an expandable frame comprising an upstream lobe and a downstream lobe separated by a neck portion, the upstream lobe comprising a concave configuration which is concave in a direction away from the downstream lobe, the neck portion forming a guidewire opening; and

a membrane carried by at least the upstream lobe, the membrane comprising a tubular portion extending in an upstream direction and at least partially through the upstream lobe, the tubular portion comprising a lumen at least partially aligned with the guidewire opening,

wherein the tubular portion comprises an reinforced portion anchored with respect to the expandable frame and a free portion extending in the upstream direction, a wall thickness of the reinforced portion being at least 3×

greater than a wall thickness of the free portion,

wherein the tubular portion is tapered in the upstream direction and across at least a majority of a length of the tubular portion,

wherein the tubular portion extends in the upstream direction prior to deployment and post-deployment, and

wherein the tubular portion is configured to transition between an open configuration in which the tubular portion is configured to receive a guidewire and a closed configuration in which the tubular portion is configured to occlude blood flow.

2. The vascular occlusion device of claim 1, wherein the tubular portion is integrally formed with a remaining portion of the membrane.

3. The vascular occlusion device of claim 1, wherein the reinforced portion is integrally formed with the free end portion.

4. The vascular occlusion device of claim 1, wherein the free portion comprises a duckbill valve.

5. The vascular occlusion device of claim 1, wherein the tubular portion is tapered at an angle of less than about five degrees.

6. The vascular occlusion device of claim 1, wherein the reinforced portion is non-porous and the free portion is porous.

7. The vascular occlusion device of claim 1, wherein a wall density of the reinforced portion is at least 10×

greater than a wall density of the free portion.

8. The vascular occlusion device of claim 1, wherein the tubular portion extends outward of an open end of the upstream lobe.

9. The vascular occlusion device of claim 1, wherein a ratio between a length of the tubular portion and a length of the upstream lobe is at least about 1:

2.

10. The vascular occlusion device of claim 1, wherein a transition between the wall thickness of the reinforced portion and the wall thickness of the free portion is a stepped transition.

11. The vascular occlusion device of claim 1, wherein the reinforced portion extends across about 50% to about 75% of a length of the tubular portion.

12. The vascular occlusion device of claim 1, wherein the reinforced portion extends across about 50% to about 75% of a length of the tubular portion.

13. A vascular occlusion device, comprising:

an expandable frame comprising a concave portion that is concave in an upstream direction, the expandable frame comprising a guidewire opening; and

a membrane carried by at least concave portion, the membrane comprising a tubular portion extending in the upstream direction and at least partially through the concave portion, the tubular portion comprising a lumen at least partially aligned with the guidewire opening,

wherein the tubular portion comprises an reinforced portion anchored with respect to the expandable frame and a free portion extending in the upstream direction, a wall thickness of the reinforced portion being at least 3×

greater than a wall thickness of the free portion,

wherein the tubular portion is tapered in the upstream direction and across at least a majority of a length of the tubular portion,

wherein the tubular portion extends in the upstream direction prior to deployment and post-deployment, and

wherein the tubular portion is configured to transition between an open configuration in which the tubular portion is configured to receive a guidewire and a closed configuration in which the tubular portion is configured to occlude blood flow.

14. The vascular occlusion device of claim 13, wherein the tubular portion is integrally formed with a remaining portion of the membrane.

15. The vascular occlusion device of claim 13, wherein the reinforced portion is integrally formed with the free end portion.

16. The vascular occlusion device of claim 13, wherein the free portion comprises a duckbill valve.

17. The vascular occlusion device of claim 13, wherein the tubular portion is tapered at an angle of less than about 5 degrees.

18. The vascular occlusion device of claim 13, wherein the reinforced portion is non-porous and the free portion is porous.

19. The vascular occlusion device of claim 13, wherein a wall density of the reinforced portion is at least 10×

greater than a wall density of the free portion.

20. The vascular occlusion device of claim 13, wherein a transition between the wall thickness of the reinforced portion and the wall thickness of the free portion is a stepped transition.