Implantable infusion device including anti-sealing reservoir

• US 10,010,667 B2
• Filed: 10/18/2011
• Issued: 07/03/2018
• Est. Priority Date: 10/18/2011
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Haase, James M., Mezera, Ronald L., Gray, John M., Whitehead, Nicholas R.
• Primary Examiner(s): Landry, II, Gerald
• Application Number:
  US13/275,690
• Publication Number:
  US 20130096537A1
• Time in Patent Office: 2,450 Days
• Field of Search: 6048901, 6048911, 60428801, 60428804, 604131, 604151
• CPC Class Codes: A61M 2005/14264 with means for compensating influence from the environment
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 2205/3341 stabilising pressure or flow to avoid excessive variation
• CPC Class Codes: A61M 2205/8218 Gas operated
• CPC Class Codes: A61M 5/14212 Pumping with an aspiration and an expulsion action
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1483 using flexible bags externally pressurised by fluid pressure

Abstract

Techniques are disclosed for reducing the accumulation of gases in an implantable infusion device. In one example, an implantable infusion device (IID) includes a housing, an expandable and contractible reservoir, and a standoff member. The expandable and contractible reservoir is configured to store a therapeutic agent and is arranged within the housing. A first end of the reservoir is configured to collapse toward a second end of the reservoir as the reservoir contracts. The standoff member is interposed between the first end and the second end of the reservoir and is configured to hold at least a portion of the first end offset from the second end when the reservoir is in a contracted state.

Claims

1. An implantable infusion device (IID) comprising:

a housing;

an expandable and contractible reservoir configured to store a therapeutic agent and arranged within the housing, wherein a first end of the reservoir is configured to move with respect to the housing and collapse toward a second end of the reservoir as the reservoir contracts, and wherein the first end of the reservoir and the second end of the reservoir are configured to contact the therapeutic agent, and wherein the reservoir defines an inlet through which the therapeutic agent is received and an outlet through which the therapeutic agent exits the reservoir, the inlet being different than the outlet; and

a standoff member interposed between the first end and the second end of the reservoir, wherein the standoff member is configured to hold at least a portion of the first end offset from the second end and maintain a flow path between the inlet and the outlet when the reservoir is in a contracted state, and wherein the first end of the reservoir comprises the standoff member.

2. The IID of claim 1, wherein the standoff member comprises a protrusion in the first end of the reservoir protruding toward the second end of the reservoir.

3. The IID of claim 2, wherein the reservoir comprises a corrugated annular side connected to the first end and the second end of the reservoir and configured to expand and contract to change a distance between the first end and the second end of the reservoir.

4. The IID of claim 3, wherein the first end is substantially planar and the annular side of the reservoir is arranged substantially perpendicular to the first end such that the reservoir comprises a cylindrical expandable and contractible reservoir.

5. The IID of claim 4, wherein each of the first end and the second end of the reservoir is at least one of circular, rectangular, or elliptical.

6. The IID of claim 2, wherein the protrusion comprises a ring-shaped protrusion generally aligned with a center of the first end.

7. The IID of claim 6, wherein the ring-shaped protrusion comprises a diameter selected based on a location of at least one of the inlet of the reservoir and an inlet to a pumping mechanism of the IID, the inlet to the pumping mechanism corresponding to the outlet of the reservoir.

8. The IID of claim 7, wherein the diameter of the ring-shaped protrusion is selected such that a space formed by the portion of the first end offset from the second end when the reservoir is in the contracted state creates the flow path between the inlet of the reservoir and the inlet to the pumping mechanism.

9. The IID of claim 6, wherein the ring-shaped protrusion comprises a height selected based on a size of the flow path created by the portion of the first end offset from the second end when the reservoir is in the contracted state.

10. The IID of claim 9, wherein the height of the ring-shaped protrusion is greater than or equal to a target fluidic resistance of the flow path.

11. The IID of claim 10, wherein the target fluidic resistance is greater than a fluidic resistance of a needle employed to at least one of purge, prime, or refill the reservoir.

12. The IID of claim 6, wherein the ring-shaped protrusion comprises a plurality of non-contiguous protrusions that form a ring comprising a center generally aligned with a center of the first end of the reservoir.

13. The IID of claim 12, wherein the non-contiguous protrusions comprise three non-contiguous protrusions that form the ring comprising the center generally aligned with the center of the first end of the reservoir.

14. The IID of claim 1, wherein the housing comprises:

a housing shield;

a bulkhead connected to the housing shield such that the housing shield and the bulkhead form a substantially closed housing chamber within which the reservoir is arranged,

wherein the second end of the reservoir is connected to the bulkhead such that the first end of the reservoir is configured to collapse toward the bulkhead as the reservoir contracts, and the standoff member is configured to hold at least a portion of the first end offset from the bulkhead when the reservoir is in the contracted state.

15. The IID of claim 14, wherein the standoff member comprises at least one protrusion in the bulkhead protruding toward the first end of the reservoir.

16. An implantable infusion device (IID) comprising:

a housing;

an expandable and contractible reservoir configured to store a therapeutic agent and arranged within the housing, the reservoir comprising;

a first end connected to the housing;

a substantially closed second end comprising a protrusion protruding toward the first end; and

a side connecting the first and the second ends to form a reservoir chamber within

which the reservoir stores the therapeutic agent,

wherein the second end of the reservoir is configured to move with respect to the housing and collapse toward the first end as the reservoir contracts,

wherein the first end of the reservoir and the second end of the reservoir are configured to contact the therapeutic agent,

wherein the reservoir defines an inlet through which the therapeutic agent is received and an outlet through which the therapeutic agent exits the reservoir, the inlet being different than the outlet, and

wherein the protrusion is configured to hold at least a portion of the second end offset from the first end and maintain a flow path between the inlet and the outlet when the reservoir is in a contracted state.

17. The IID of claim 16, wherein the second end is substantially planar and the side of the reservoir is a corrugated annular side substantially perpendicular to the second end such that the reservoir comprises a cylindrical expandable and contractible reservoir.

18. The IID of claim 17, wherein each of the first end and the second end of the reservoir is at least one of circular, rectangular, or elliptical.

19. The IID of claim 16, wherein the protrusion comprises a ring-shaped protrusion generally aligned with a center of the second end.

20. The IID of claim 19, wherein the ring-shaped protrusion comprises a diameter selected based on a location of at least one of the inlet of the reservoir and an inlet to a pumping mechanism of the IID, the inlet to the pumping mechanism corresponding to the outlet of the reservoir.

21. The IID of claim 20, wherein the diameter of the ring-shaped protrusion is selected such that a space formed by the portion of the second end offset from the first end when the reservoir is in the contracted state creates the flow path between the inlet of the reservoir and the inlet to the pumping mechanism.

22. The IID of claim 19, wherein the ring-shaped protrusion comprises a height selected based on a size of the flow path created by the portion of the second end offset from the first end when the reservoir is in the contracted state.

23. The IID of claim 22, wherein the height of the ring-shaped protrusion is greater than or equal to a target fluidic resistance of the flow path.

24. The IID of claim 23, wherein the target fluidic resistance is greater than a fluidic resistance of a needle employed to at least one of purge, prime, or refill the reservoir.

25. The IID of claim 19, wherein the ring-shaped protrusion comprises a plurality of non-contiguous protrusions that form a ring comprising a center generally aligned with a center of the second end.

26. The IID of claim 25, wherein the non-contiguous protrusions comprise three non-contiguous protrusions that form the ring comprising the center generally aligned with the center of the second end.

27. The IID of claim 16, wherein the housing comprises:

a housing shield;

a bulkhead connected to the housing shield such that the housing shield and the bulkhead form a substantially closed housing chamber within which the reservoir is arranged,

wherein the first end of the reservoir is connected to the bulkhead such that the second end of the reservoir is configured to collapse toward the bulkhead as the reservoir contracts and the protrusion is configured to hold at least a portion of the second end offset from the bulkhead when the reservoir is in the contracted state.

28. A reservoir configured to store a therapeutic agent in an implantable infusion device (IID), the reservoir comprising:

a first end comprising a ring-shape that forms an opening toward a center of the first end;

a second substantially closed planar end comprising a protrusion protruding toward the first end, wherein the second end is configured to move with respect to a housing of the IID, and wherein the first end and the second end are configured to contact the therapeutic agent; and

a corrugated annular side substantially perpendicular to the first and the second ends and connecting the first and the second ends to form a cylindrical chamber within which the reservoir stores the therapeutic agent,

wherein the corrugated annular side is configured to expand and contract to change a distance between the first end and the second end of the reservoir,

wherein the reservoir defines an inlet through which the therapeutic agent is received and an outlet through which the therapeutic agent exits the reservoir, the inlet being different than the outlet, and

wherein the protrusion is configured to hold at least a portion of the second end offset from the first end and maintain a flow path between the inlet and the outlet when the reservoir is in a contracted state.

29. An implantable infusion device (IID) comprising:

a housing;

an expandable and contractible reservoir configured to store a therapeutic agent and arranged within the housing, wherein a first end of the reservoir is configured to move with respect to the housing and collapse toward a second end of the reservoir as the reservoir contracts, and wherein the first end of the reservoir and the second end of the reservoir are configured to contact the therapeutic agent, and wherein the reservoir defines an inlet through which the therapeutic agent is received and an outlet through which the therapeutic agent exits the reservoir, the inlet being different than the outlet; and

a standoff means interposed between the first end and the second end of the reservoir, wherein the standoff means is for holding at least a portion of the first end offset from the second end and maintain a flow path between the inlet and the outlet when the reservoir is in a contracted state, and wherein the first end of the reservoir comprises the standoff means.