Drug delivery device

• US 10,010,671 B2
• Filed: 08/11/2014
• Issued: 07/03/2018
• Est. Priority Date: 05/07/2006
• Status: Active Grant

• Current Assignee: United Therapeutics Corporation
• Original Assignee: SteadyMed Ltd. (United Therapeutics Corporation)
• Inventors: Genosar, Amir, Aurbach, Doron, Markevich, Elena, Salitra, Grigory, Goldstein, Jonathan, Levi, Mikhail, Fleischer, Niles, Bachar, Yehuda, Aldar, Yossi
• Primary Examiner(s): Yanchuk, Stephen J
• Application Number:
  US14/456,416
• Publication Number:
  US 20150017493A1
• Time in Patent Office: 1,422 Days
• CPC Class Codes: A61M 2005/14204 with gas-producing electrochemical cell
• CPC Class Codes: A61M 2005/14252 with needle insertion means
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 2205/35 Communication
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/14586 pressurised by means of a flexible diaphragm
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61M 5/2046 Media being expelled from injector by gas generation, e.g. explosive charge
• CPC Class Codes: H01M 10/02 Details of electrodes H01M4/00; of non-active parts H01M50/00
• CPC Class Codes: H01M 10/05 Accumulators with non-aqueous electrolyte H01M10/39 takes precedence
• CPC Class Codes: H01M 10/42 Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells H01M10/60 takes precedence
• CPC Class Codes: H01M 2220/30 Batteries in portable systems, e.g. mobile phone, laptop
• CPC Class Codes: H01M 50/10 Primary casings; Jackets or wrappings
• CPC Class Codes: H01M 50/102 characterised by their shape or physical structure
• CPC Class Codes: Y02E 60/10 : Energy storage using batteries

Abstract

Embodiments include a displacement-generating battery cell for driving a drug-delivery device. The cell includes at least one volume-changing element. The cell also includes a housing formed according to a concertina-shaped design with folds in the walls thereof and containing an internal chemical reaction system. The arrangement of the chemical reaction system is such that as the cell is discharged, the volume-changing element expands, thereby lengthening the battery and thus reducing the extent of said folds, such that the cell becomes taller to reflect the expansion of the volume-changing component.

Claims

1. A displacement-generating battery cell for driving a drug-delivery device and comprising at least one volume-changing element,

said cell comprising a housing formed according to a concertina-shaped design with folds in the walls thereof and containing an internal chemical reaction system,

said chemical reaction system comprising a first electrode and a second electrode,

the second electrode being said volume-changing element,

the arrangement of said chemical reaction system and said housing being such that:

an expansion of the volume-changing element in a direction lengthens the cell and thus reduces the extent of said folds,

the cell becomes taller in the direction to reflect the expansion of said volume-changing element, and

the expansion of the volume-changing element increases the surface area between the first electrode and the second electrode, and

the chemical reaction system being configured such that discharging of the cell results in the expansion of the volume-changing element in the direction.

2. A displacement-generating battery cell according to claim 1, wherein the volume of the displacement-generating battery cell is changed as its respective electrical capacity is changed.

3. A displacement-generating battery cell according to claim 1, wherein at least one component of the displacement-generating battery cell undergoes a volume change of at least 20%.

4. A displacement-generating battery cell according to claim 1, wherein at least one component of the displacement-generating battery cell undergoes a volume change of at least 30%.

5. A displacement-generating battery cell according to claim 1, wherein the displacement derived from the displacement-generating battery cell exerts a force of at least 1 kg/sq cm.

6. A displacement-generating battery cell according to claim 1, wherein the displacement derived from the displacement-generating battery cell exerts a force of at least 10 kg/sq cm.

7. A displacement-generating battery cell according to claim 1, the arrangement of said chemical reaction system and said housing further being such that a contraction of the volume-changing element in the direction shortens the battery and thus increases the extent of said folds, such that the cell becomes shorter in the direction to reflect the contraction of said volume-changing element, and

the chemical reaction system being configured such that charging the cell results in the contraction of the volume-changing element in the direction.

8. A displacement-generating battery cell according to claim 1, wherein the displacement-generating battery cell has a diameter of between 10 and 30 mm.

9. A displacement-generating battery cell according to claim 1, wherein the displacement-generating battery cell has a diameter of between 20 and 60 mm.

10. A displacement-generating battery cell according to claim 1, wherein the displacement-generating battery cell comprises an electrode, and the electrode comprises a pressed, pasted or sintered porous structure.

11. A displacement-generating battery cell according to claim 1, where said chemical reaction system is chosen from the group consisting of Li—

Sn, (Li)LiC₆—

Sn, Fe—

LaNi₅, lithium-lead, lithium-antimony, lithium-silicon and lithium bismuth.

12. A displacement-generating battery cell according to claim 1, wherein the displacement-generating battery cell comprises an electrode, and the electrode comprises tin, iron or lithium alloys.

13. A displacement-generating battery cell according to claim 1, wherein the displacement-generating battery cell comprises an electrode, and the electrode comprises lithium-aluminum, lithium-magnesium, lithium-aluminum-magnesium, lithium-lead, lithium-antimony, lithium-silicon or lithium-bismuth.

14. A displacement-generating battery cell according to claim 1, wherein the displacement-generating battery cell comprises an organic solvent or a polymer electrolyte together with a lithium ion-providing salt.

15. A displacement-generating battery cell according to claim 1, wherein the displacement-generating battery cell comprises an electrode, and the electrode expands over 250% in volume during discharge.

16. A displacement-generating battery cell according to claim 1, wherein the displacement-generating battery cell comprises a tin cathode, a lithium anode and an electrolyte.

17. A displacement-generating battery cell according to claim 1, wherein the displacement-generating battery cell comprises an electrolyte, and the electrolyte comprises a solvent of a mixture of ethylene carbonate and ethyl methyl carbonate with dissolved lithium hexafluorophosphate.

18. A displacement-generating battery cell according to claim 1, wherein the displacement-generating battery cell comprises a porous, tin cathode.

19. A displacement-generating battery cell according to claim 1, wherein the displacement-generating battery cell comprises a plurality of anodes and a plurality of cathodes.

20. A displacement-generating battery cell according to claim 1, wherein said chemical reaction system is non-gassing.

21. A displacement-generating battery cell according to claim 1, wherein:

said chemical reaction system is an electrochemical reaction system,

said chemical reaction system comprises an electrolyte,

the first electrode is an anode of the electrochemical reaction system,

the second electrode is a cathode of the electrochemical reaction system, and

the chemical reaction system is configured such that discharging of the cell results in the expansion of the volume-changing element by ions derived from the first electrode penetrating the second electrode.

22. A displacement-generating battery cell, the displacement-generating battery cell comprising:

a housing having a concertina-shaped design with folds in the walls thereof, the housing having a first end and a second end, a distance between the first and second ends of the housing defining a housing length; and

an electrochemical reaction system comprising an anode and an expandable cathode, the expandable cathode having a first end and a second end, a distance between the first and second ends of the expandable cathode defining a cathode length,

wherein the electrochemical reaction system is contained within the housing, and

wherein the first and second ends of the housing are coupled with the first and second ends of the expandable cathode, respectively, such that an expansion of the cathode that increases the cathode length causes a corresponding increase in the housing length and such that the expansion of the cathode increases the surface area between the anode and cathode.