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Immunological reagents and uses therefor

  • US 10,011,602 B2
  • Filed: 07/05/2013
  • Issued: 07/03/2018
  • Est. Priority Date: 07/06/2012
  • Status: Active Grant
First Claim
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1. A method of detecting the presence of MAIT cells in a biological sample from a subject, the method comprising the steps ofa) contacting the biological sample with antigen presenting cells expressing MR1 bound to a ligand or a soluble form of MR1 bound to a ligand, under conditions that would allow binding of the MR1 or the soluble form of MR1 with MATT cells present in the sample, wherein the ligand is a compound selected from the group consisting of rRL-6HM, rRL-6AM, RL-6M, RP-5PA, 6-formyl pterin, acetyl 6-formyl pterin, 6-methyl-7-hydroxy-8-ribityl lumazine, and 6-,7-dimethyl-8-Ribityl Lumazine;

  • andb) detecting the presence of MAIT cell bound MR1 or MAIT cell bound soluble form of MR1 in the biological sample,thereby detecting the presence of MAIT cells in a biological sample from a subject.

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