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Method and device for long-term monitoring of arterial vascular stiffness and vascular calcification of a patient

  • US 10,016,138 B2
  • Filed: 04/11/2013
  • Issued: 07/10/2018
  • Est. Priority Date: 04/11/2012
  • Status: Active Grant
First Claim
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1. A method for long-term monitoring arterial vascular stiffness of a patient comprising the steps of:

  • non-invasive measurement of a pressure pulse wave as a function of time, caused by a cardiac contraction of the patient, in a plurality of successive intervals of time based on at least one pressure pulse wave occurring per interval of time and corresponding to a series of successive extracorporeal blood treatment sessions of the patient or including a series of successive extracorporeal blood treatment sessions of the patient,non-invasively determining one time the length of the descending aorta of the patient, characterized in that the length of the descending aorta of the patient (L2) defined as the distance between the tip of the aortic arch and the aortic bifurcation is calculated according to at least one of the equations
    L2=kJS·

    L
    JS, where 0.6

    k
    JS

    1,whereinL2 denotes the length of the descending aorta of the patient,kJS denotes a first dimensionless correction factor, andLJS denotes the distance between the jugular and the pubic symphysis of the patient lying down,
    L2=kJBS·

    L
    JBS, where 0.8

    k
    JBS

    1.2,whereinL2 denotes the length of the descending aorta of the patient,kJBS denotes a second dimensionless correction factor, andLJBS denotes the distance between the jugular and the umbilicus of the patient, and
    L2

    ·

    H


    β

    , where α

    =3.10 and β

    =7.00,whereinL2 denotes the length of the descending aorta of the patient in mm andH denotes the height of the patient, standing up, in cm,storing the determined length of the descending aorta of the patient on a non-transitory computer readable medium unambiguously assigned to the patient,evaluation of the measured pressure pulse waves as a function of time in the plurality of successive intervals of time based on the at least one pressure pulse wave per interval of time and calculating a pulse wave transit time (PTT) in the descending aorta of the patient from a smoothing of the measured pressure pulse waves as a function of time for the at least one pressure pulse wave per interval of time, wherein the pulse transit time (PTT) in the descending aorta is calculated as the difference between the time of a detected peak of the reflection wave or a detected turning point of the reflection wave in the at least one pulse pressure wave and the time of a systolic peak in the at least one pulse pressure wave,saving the calculated pulse wave transit time for a majority of successive measurement intervals,calculating a trend of the pulse wave transit time from the saved pulse wave transit times,storing the trend of the pulse wave transit time as a time series on the non-transitory computer readable medium unambiguously assigned to the patient, andmonitoring the stored trend of the pulse wave transit time for a change in the pulse wave transit time indicating a change in the arterial vascular stiffness of the patient.

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