System and method for monitoring and treating a surface of a subject

• US 10,016,164 B2
• Filed: 07/10/2013
• Issued: 07/10/2018
• Est. Priority Date: 07/10/2012
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Evans, Conor L., Apiou, Gabriela, Birngruber, Reginald, Nichols, Alexander J., Rousakis, Emmanouil, Li, Zongxi
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Fardanesh, Marjan
• Application Number:
  US14/413,571
• Publication Number:
  US 20150182166A1
• Time in Patent Office: 1,826 Days
• CPC Class Codes: A61B 2562/12 Manufacturing methods specially adapted for producing sensors for in-vivo measurements
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/14556 by fluorescence A61B5/14555 takes precedence
• CPC Class Codes: A61B 5/443 Evaluating skin constituents, e.g. elastin, melanin, water
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6833 Adhesive patches
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61F 2013/0097 oxygen content
• CPC Class Codes: A61K 49/0015 Phosphorescence
• CPC Class Codes: C07D 487/22 in which the condensed system contains four or more hetero rings

Abstract

A system and method are provided for the design and assembly of a device including a sensor capable and a compatible matrix material incorporated into a dressing. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions, and the matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte.

Claims

1. A device comprising:

a sensor configured to detect a concentration of an analyte selected from the group consisting of molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma and tissue, and hydrogen ions;

a therapeutic portion configured to deliver at least one of a therapeutic agent, a biomarker, and a diagnostic agent to a tissue surface of a patient in response to a stimulus or stimuli selected from the group consisting of chemical, mechanical pressure, light and ultrasound;

a matrix compatible with said sensor and the therapeutic portion, at least a portion of said matrix is at least one of accessible and permeable to said analyte; and

a dressing comprising said matrix and said sensor and the therapeutic portion;

wherein said device emits a signal in response to the concentration of said analyte detected by said sensor by modulation of inelastic scattering of an electromagnetic field, including at least one of phosphorescence, fluorescence, and absorption.

2. The device of claim 1, wherein said sensor is configured to interact with a tissue surface of a patient.

3. The device of claim 1, wherein said dressing is configured to be reversibly affixed to a tissue surface of a patient.

4. The device of claim 1, wherein said sensor comprises a meso-unsubstituted porphyrin.

5. The device of claim 1, wherein said therapeutic portion further comprises at least one of a passive and an actuated therapeutic release mechanism configured to release the therapeutic agent to tissue surfaces of the patient in response to applied light.

6. The device of claim 5, wherein said actuated therapeutic release mechanism comprises a light actuated polymeric matrix configured to be responsive to the signal.

7. The device of claim 6, wherein said polymeric matrix includes polydimethylsiloxane (PDMS).

8. The device of claim 1, further comprising a display device configured to display an active, real-time map of a parameter associated with said analyte.

9. A method of manufacturing a device for detecting an analyte and delivering at least one of a therapeutic agent, a biomarker, and a diagnostic agent to a tissue surface of a patient, the method comprising the steps of:

(a) selecting a sensor configured to detect a concentration of an analyte including at least one of molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma and tissue, and hydrogen ions;

(b) selecting a compatible matrix based on a chemical nature of said sensor;

(c) selecting a therapeutic portion configured to deliver at least one of a therapeutic agent, a biomarker, and a diagnostic agent to a tissue surface of a patient in response to a stimulus or stimuli selected from the group consisting of chemical, mechanical pressure, light and ultrasound;

(d) enmeshing said sensor and the therapeutic portion in said compatible matrix, at least a portion of said matrix accessible to said analyte; and

(e) incorporating said matrix into a dressing;

wherein said dressing is configured to emit a signal that varies in response to the concentration of said analyte detected by said sensor.

10. The method of claim 9, wherein said sensor is configured to interact with a tissue surface of a patient.

11. The method of claim 9, wherein said sensor comprises a meso-unsubstituted metallated porphyrin.

12. A kit for detecting an analyte and delivering at least one of a therapeutic agent, a biomarker, and a diagnostic agent to a tissue surface of a patient, the kit comprising:

a dressing comprising a sensor configured to detect at least one analyte, and a therapeutic portion configured to deliver at least one of a therapeutic agent, a biomarker, and a diagnostic agent to a tissue surface of a patient in response to a stimulus or stimuli selected from the group consisting of chemical, mechanical pressure, light and ultrasound, and a matrix compatible with said sensor and the therapeutic portion; and

a detector configured to actuate said sensor and measure a signal as a function of a mapped position on at least one of a surface of and within said dressing; and

wherein said signal is responsive to the presence of said at least one analyte proximate to said surface of said dressing and generated by modulation of inelastic scattering of an electromagnetic field.

13. The kit of claim 12, wherein said sensor is configured to interact with a tissue surface of a patient.

14. The kit of claim 12, wherein said sensor comprises a meso-unsubstituted metallated porphyrin.

15. The kit of claim 12, further comprising an interacting portion configured to actuate at least one of said sensor and said therapeutic portion in response to applied light.

16. A kit of claim 15, wherein said therapeutic portion configured for local and/or remote communication with an external system, network, or computer through at least one of wired communication and wireless communication.

17. The kit of claim 12, further comprising a display device mcchanism configured to display an active, real-time map of a parameter associated with said analyte.

18. The kit of claim 12, wherein said detector is further configured to elicit time-resolved emitted signals from at least one of said dressing device and a surrounding environment.

19. The kit of claim 12, wherein said detector is further configured to report analyte properties including concentration.

20. The kit of claim 12 wherein said detector is further configured to communicate with at least one of a network, a display, and a computer system.

21. The kit of claim 12 wherein the dressing is configured to be applied to a tissue surface of a patient as a liquid and form a solid on the tissue surface of the patient.