Accessing predictive data

• US 10,016,249 B2
• Filed: 10/23/2006
• Issued: 07/10/2018
• Est. Priority Date: 09/08/2005
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Inventors: Jung, Edward K. Y., Levien, Royce A., Lord, Robert W., Malamud, Mark A., Rinaldo, Jr., John D., Wood, Jr., Lowell L
• Primary Examiner(s): Chng, Joy
• Application Number:
  US11/585,662
• Publication Number:
  US 20070118164A1
• Time in Patent Office: 4,278 Days
• Field of Search: 705 2- 3
• CPC Class Codes: A61B 34/10 Computer-aided planning, simulation or modelling of surgical operations
• CPC Class Codes: A61B 90/36 Image-producing devices or illumination devices not otherwise provided for
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

An apparatus, device, methods, computer program product, and system are described that provide a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, the first possible outcome based on at least one dataset associated with at least one predictive basis, and apply a filter criteria to the at least one dataset to provide a modified graphical illustration of a second possible outcome of the use of the treatment parameter.

Claims

1. A system comprising:

circuitry configured for receiving at least one genetic characteristic representative of at least one patient associated with at least one treatment parameter;

circuitry configured for receiving input identifying at least one direct end target associated with the at least one treatment parameter, the at least one direct end target including at least one target-related tissue ancestry-correlated binding site;

circuitry configured for providing a first possible treatment agent, the first possible treatment agent based at least partly on at least one first predictive basis associated with the at least one treatment parameter and the at least one direct end target;

circuitry configured for applying a filter criteria based at least partly on at least one second predictive basis associated with the received at least one genetic characteristic, the at least one second predictive basis indicative of a second possible treatment agent; and

circuitry configured for determining whether one of the first possible treatment agent or the second possible treatment agent is a preferred treatment agent for the at least one patient based at least partly on the received at least one genetic characteristic.

2. The system of claim 1, wherein the circuitry configured for providing a first possible treatment agent, the first possible treatment agent based at least partly on at least one first predictive basis associated with the at least one treatment parameter and the at least one direct end target comprises:

circuitry configured for providing a graphical illustration of at least part of a body that visually indicates a first possible outcome of a use of a treatment agent with respect to efficacy of the treatment agent, the first possible outcome based at least partly on the at least one first predictive basis.

3. The system of claim 1, wherein the circuitry configured for identifying at least one direct end target associated with at least one treatment parameter comprises:

circuitry configured for identifying at least one direct intermediate target associated with the at least one treatment parameter.

4. The system of claim 1, wherein the circuitry configured for providing a first possible treatment agent, the first possible treatment agent based at least partly on at least one first predictive basis associated with the at least one treatment parameter and the at least one direct end target comprises:

circuitry configured for providing a graphical illustration, the graphical illustration including the at least one discriminated intermediate target associated with at least one body portion.

5. The system of claim 1, wherein the circuitry configured for providing a first possible treatment agent comprises:

circuitry configured for identifying at least one treatment agent associated with at least one of the at least one direct end target or the at least one treatment parameter.

6. The system of claim 1, wherein the circuitry configured for receiving input identifying at least one direct end target associated with the at least one treatment parameter comprises:

circuitry configured for identifying at least one treatment agent precursor associated with at least one of the at least one direct end target or the at least one treatment parameter.

7. The system of claim 1, wherein the circuitry configured for providing a first possible treatment agent, the first possible treatment agent based at least partly on at least one first predictive basis associated with the at least one treatment parameter and the at least one direct end target comprises:

circuitry configured for providing an indication of efficacy associated with the first possible treatment agent, the indication of efficacy at least partly based on the received at least one genetic characteristic.

8. The system of claim 1, wherein the circuitry configured for providing a first possible treatment agent, the first possible treatment agent based at least partly on at least one first predictive basis associated with the at least one treatment parameter and the at least one direct end target comprises:

circuitry configured for providing a graphical illustration of at least part of the body that visually indicates a potential risk associated with the first possible outcome of the use of the treatment agent.

9. The system of claim 1, wherein the circuitry configured for applying a filter criteria based at least partly on at least one second predictive basis associated with the received at least one genetic characteristic, the at least one second predictive basis indicative of a second possible treatment agent comprises:

circuitry configured for applying at least one of the following types of filter criteria to provide a second possible treatment agent;

human study, animal study, computer simulation, date, region, or protocol.

10. The system of claim 1, wherein the circuitry configured for providing a first possible treatment agent, the first possible treatment agent based at least partly on at least one first predictive basis associated with the at least one treatment parameter and the at least one direct end target comprises:

circuitry configured for providing a first possible outcome of a use of a treatment agent with respect to one or more of the following;

organ, organ system, organ subsystem, diseased tissue, and healthy tissue.

11. The system of claim 1, wherein the circuitry configured for providing a first possible treatment agent, the first possible treatment agent based at least partly on at least one first predictive basis associated with the at least one treatment parameter and the at least one direct end target comprises:

circuitry configured for providing a first systemic consequence of a use of a treatment agent based at least partly on the at least one first predictive basis associated with the at least one treatment parameter and based at least partly on the received at least one genetic characteristic.

12. The system of claim 1, wherein the circuitry configured for providing a first possible treatment agent, the first possible treatment agent based at least partly on at least one first predictive basis associated with the at least one treatment parameter and the at least one direct end target comprises:

circuitry configured for providing a first possible outcome of a use of at least one of the following types of treatment agents;

medication, imaging, and radio-immunotherapy.

13. The system of claim 1, wherein the circuitry configured for receiving input identifying at least one direct end target associated with the at least one treatment parameter, the at least one direct end target including at least one target-related tissue ancestry-correlated binding site comprises:

circuitry configured for deriving at least one three-dimensional representation of a particular patient based on data received from one or more image sensors, and

wherein the circuitry configured for providing a first possible treatment agent, the first possible treatment agent based at least partly on at least one first predictive basis associated with the at least one treatment parameter and the at least one direct end target includes at least;

circuitry configured for providing a graphical indication associated with the at least one three-dimensional representation of the individual regarding a first possible outcome of a use of a treatment agent, the first possible outcome based at least partly on the at least one first predictive basis.

14. The system of claim 1, wherein the circuitry configured for providing a first possible treatment agent, the first possible treatment agent based at least partly on at least one first predictive basis associated with the at least one treatment parameter and the at least one direct end target comprises:

circuitry configured for providing a first possible treatment agent based at least partly on an indication that the at least one directed target is diseased, and

wherein the circuitry configured for applying a filter criteria based at least partly on at least one second predictive basis associated with the received at least one genetic characteristic, the at least one second predictive basis indicative of a second possible treatment agent includes at least

circuitry configured for applying a filter criteria based at least partly on at least one indication that the first possible treatment agent is contraindicated for the at least one patient, the at least one indication based at least partly on the received at least one genetic characteristic.

15. The system of claim 1, further comprising:

circuitry configured for identifying at least one discriminated end target associated with the at least one treatment parameter based at least partly on at least one indication that the at least one treatment parameter is associated with a high risk of negative impact on the at least one discriminated end target.

16. The system of claim 1, wherein the circuitry configured for receiving input identifying at least one direct end target associated with the at least one treatment parameter comprises:

circuitry configured for identifying at least one treatment parameter associated with at least one end target based at least partly on at least one indication that at least one portion of the end target is diseased, and

wherein the circuitry configured for applying a filter criteria based at least partly on at least one second predictive basis associated with the received at least one genetic characteristic, the at least one second predictive basis indicative of a second possible treatment agent includes at least;

circuitry configured for determining that at least one portion of the end target is non-diseased based at least partly on the received at least one genetic characteristic

circuitry configured for providing at least one probabilistic outcome associated with application of the treatment parameter to the direct end target;

circuitry configured for providing at least one probabilistic outcome associated with at least one side effect of the at least one treatment parameter associated with the at least one portion of the end target that is non-diseased; and

circuitry configured for providing at least one probabilistic outcome associated with application of the treatment parameter to the portion of the end target that is non-diseased.

17. The system of claim 1, wherein the circuitry configured for receiving input identifying at least one direct end target associated with the at least one treatment parameter, the at least one direct end target including at least one target-related tissue ancestry-correlated binding site comprises:

circuitry configured for identifying at least one target-related tissue ancestry-correlated binding agent associated with a preferred treatment based at least partly on the at least one treatment parameter; and

circuitry configured for identifying body portions containing at least one target-related tissue ancestry-correlated binding site associated with the at least one target-related tissue ancestry-correlated binding agent.

18. The system of claim 1, further comprising:

circuitry configured for determining whether at least one discriminated end target associated with the at least one treatment parameter includes the at least one target-related tissue ancestry-correlated binding site associated with the at least one direct end target, and

wherein the circuitry configured for determining whether one of the first possible treatment agent or the second possible treatment agent is a preferred treatment agent for the at least one patient based at least partly on the received at least one genetic characteristic includes at least;

circuitry configured for determining an alternative treatment agent based on the determination whether the at least one discriminated end target associated with the at least one treatment parameter includes the at least one target-related tissue ancestry-correlated binding site associated with the at least one direct end target.

19. The system of claim 1, wherein the circuitry configured for receiving at least one genetic characteristic representative of at least one patient associated with at least one treatment parameter comprises:

circuitry configured for receiving at least one genetic characteristic representative of the at least one patient associated with the at least one treatment parameter via at least one touch-input enabled graphical user interface.

20. The system of claim 1, wherein the circuitry configured for receiving input identifying at least one direct end target associated with the at least one treatment parameter comprises:

circuitry configured for highlighting at least one body portion on at least one touch-enabled visual display, the highlighting including the at least one direct end target at least partly based on the received input identifying the at least one direct end target.

21. The system of claim 1, wherein the circuitry configured for receiving input identifying at least one direct end target associated with the at least one treatment parameter comprises:

circuitry configured for highlighting at least one body portion on at least one touch-enabled visual display, the highlighting including at least one discriminated end target at least partly based on received input identifying at least one discriminated end target.

22. The system of claim 1, wherein the circuitry configured for receiving at least one genetic characteristic representative of at least one patient associated with at least one treatment parameter comprises:

circuitry configured for setting the at least one genetic characteristic as a primary key in a set of relational tables.

23. The system of claim 22, wherein the circuitry configured for applying a filter criteria based at least partly on at least one second predictive basis associated with the received at least one genetic characteristic, the at least one second predictive basis indicative of a second possible treatment agent comprises:

circuitry configured for identifying at least one foreign key within one or more relational tables including one or more treatment agents, the at least one foreign key corresponding to the primary key; and

circuitry configured for eliminating from consideration as a possible treatment agent any record that does not include the at least one foreign key.

24. A method for determining probable outcomes of treatments, comprising:

receiving at least one genetic characteristic representative of at least one patient associated with at least one treatment parameter;

receiving input identifying at least one direct end target associated with the at least one treatment parameter, the at least one direct end target including at least one target-related tissue ancestry-correlated binding site;

providing a first possible treatment agent, the first possible treatment agent based at least partly on at least one first predictive basis associated with the at least one treatment parameter and the at least one direct end target;

applying a filter criteria based at least partly on at least one second predictive basis associated with the received at least one genetic characteristic, the at least one second predictive basis indicative of a second possible treatment agent; and

determining whether one of the first possible treatment agent or the second possible treatment agent is a preferred treatment agent for the at least one patient based at least partly on the received at least one genetic characteristic.

25. A computer program product comprising:

a non-transitory signal-bearing medium bearing one or more instructions that, when executed by at least one computer, configure the at least one computer to perform operations including at least;

receive at least one genetic characteristic representative of at least one patient associated with at least one treatment parameter;

receive input identifying at least one direct end target associated with the at least one treatment parameter, the at least one direct end target including at least one target-related tissue ancestry-correlated binding site;

provide a first possible treatment agent, the first possible treatment agent based at least partly on at least one first predictive basis associated with the at least one treatment parameter and the at least one direct end target;

apply a filter criteria based at least partly on at least one second predictive basis associated with the received at least one genetic characteristic, the at least one second predictive basis indicative of a second possible treatment agent; and

determine whether one of the first possible treatment agent or the second possible treatment agent is a preferred treatment agent for the at least one patient based at least partly on the received at least one genetic characteristic.