Biphasic implant device providing joint fluid therapy

• US 10,016,278 B2
• Filed: 06/30/2009
• Issued: 07/10/2018
• Est. Priority Date: 06/30/2009
• Status: Active Grant

• Current Assignee: DSM IP Assets BV (DSM-Firmenich AG)
• Original Assignee: DSM IP Assets BV (DSM-Firmenich AG)
• Inventors: Bradica, Gino, Wattengel, William Christian, Ringeisen, Timothy A.
• Primary Examiner(s): OU, JING RUI
• Application Number:
  US12/495,611
• Publication Number:
  US 20100331865A1
• Time in Patent Office: 3,297 Days
• Field of Search: 623 2372- 2374, 606151, 606213, 424422-426, 524 96
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2002/30014 differing in elasticity, stiffness or compressibility
• CPC Class Codes: A61F 2002/30028 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61F 2002/30031 differing in wettability, e.g. in hydrophilic or hydrophobic behaviours
• CPC Class Codes: A61F 2002/30052 differing in electric or magnetic properties
• CPC Class Codes: A61F 2002/30088 Phase change materials [PCM], e.g. for storing latent heat
• CPC Class Codes: A61F 2002/30332 Conically- or frustoconically-shaped protrusion and recess
• CPC Class Codes: A61F 2002/3092 having an open-celled or open-pored structure
• CPC Class Codes: A61F 2002/30971 Laminates, i.e. layered products
• CPC Class Codes: A61F 2002/4495 having a fabric structure, e.g. made from wires or fibres
• CPC Class Codes: A61F 2210/008 Phase change materials [PCM], e.g. for storing latent heat
• CPC Class Codes: A61F 2220/0033 made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
• CPC Class Codes: A61F 2250/0018 differing in elasticity, stiffness or compressibility
• CPC Class Codes: A61F 2250/0043 differing in electric properties, e.g. in electrical conductivity, in galvanic properties
• CPC Class Codes: A61F 2250/0051 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61F 2250/0056 differing in wettability, e.g. in hydrophilic or hydrophobic behaviours
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/48 : with macromolecular fillers
• CPC Class Codes: A61L 27/50 : Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/52 : Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/56 : Porous materials, e.g. foams or sponges

Abstract

Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant.

Claims

1. A device for repair or replacement of tissue deficiencies in a living being, comprising at least two juxtaposed materials that form a malleable matrix capable of transmitting forces in the form of a vortex ring, with a first material of said at least two juxtaposed materials presenting itself as a hydrogel capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading, said hydrogel encapsulating a second material of said at least two juxtaposed materials, the second material being in the form of a three-dimensional network of fibers, wherein the fibers making up the network of fibers are interwoven or knitted, thereby forming connecting nodes or knots, and the distance between connecting nodes or knots is not less than 2 millimeters and not more than 1.5 times a diameter of said device, wherein said device is formed as a plug having a circular cross-section and shaped to fill a void or defect created through a cartilage layer and into underlying bone, wherein the three-dimensional network of fibers are randomly located within said hydrogel, and further wherein said device is at least partially resorbable by the living being.

2. The device of claim 1 wherein the matrix is porous.

3. The device of claim 1 wherein the matrix is configured to become malleable upon hydration.

4. The device of claim 1 wherein the matrix is configured to return to its original shape after deformation.

5. The device of claim 1 wherein the fiber material is suspended within the hydrogel material.

6. The device of claim 1 wherein the matrix also contains an additive in the form of a particulate or biologically active agent.

7. The device of claim 1 wherein the juxtaposed materials are selected from the groups consisting of ceramics, natural polymers, synthetic polymer and combinations thereof.

8. The device of claim 1 wherein the matrix is attached to a porous rigid base.

9. The device of claim 1 wherein the matrix is attached a rigid base material selected from the groups consisting of metals, polymers, ceramics or combinations thereof.

10. The device of claim 1, wherein the second material comprises collagen.

11. A device for repair or replacement of tissue deficiencies, comprising at least two juxtaposed materials that form a malleable matrix capable of transmitting forces in the form of a gyre, wherein a first material of said at least two juxtaposed materials is a collagen hydrogel, said collagen hydrogel encapsulating a second material of said at least two juxtaposed materials, the second material being in the form of a three-dimensional network of collagen fibers, wherein the fibers making up the network of collagen fibers are interwoven or knitted, thereby forming connecting nodes or knots, and the distance between connecting nodes or knots is not less than 2 millimeters and not greater than 1.5 times a diameter of said device, wherein said device is formed as a plug having a circular cross-section and shaped to fill a void or defect created through a cartilage layer and into underlying bone, wherein the three-dimensional network of collagen fibers are randomly located within said collagen hydrogel.

12. The device of claim 11, wherein the matrix is porous.

13. A device for repair or replacement of tissue deficiencies, comprising at least two juxtaposed materials that form a malleable matrix, said juxtaposed materials comprising a hyaluronic acid hydrogel encapsulating a three-dimensional network of chitosan fibers, wherein the fibers making up the network of chitosan fibers are interwoven or knitted, thereby forming connecting nodes or knots, and the distance between connecting nodes or knots is not less than 2 millimeters and not greater than 1.5 times a diameter of said device, wherein said device is formed as a plug having a circular cross-section and shaped to fill a void or defect created through a cartilage layer and into underlying bone, wherein the three-dimensional network of chitosan fibers are randomly located within the hyaluronic acid hydrogel.

14. The device of claim 13, wherein the matrix is porous.