×

Trilayer coated pharmaceutical packaging

  • US 10,016,338 B2
  • Filed: 12/20/2016
  • Issued: 07/10/2018
  • Est. Priority Date: 03/11/2013
  • Status: Active Grant
First Claim
Patent Images

1. A filled package comprising:

  • a vessel having a lumen defined at least in part by a wall, the wall having an interior surface facing the lumen, an outer surface, and a coating set on the interior surface comprising a tie coating or layer, a barrier coating or layer, and a pH protective coating or layer;

    the tie coating or layer comprising SiOxCy wherein x is from about 0.5 to about 2.4 and y is from about 0.6 to about 3, the tie coating or layer having an interior surface facing the lumen and an outer surface facing the wall interior surface;

    the barrier coating or layer comprising SiOx, wherein x is from 1.5 to 2.9, from 2 to 1000 nm thick, the barrier coating or layer of SiOx having an interior surface facing the lumen and an outer surface facing the interior surface of the tie coating or layer, the barrier coating or layer being effective to reduce the ingress of atmospheric gas into the lumen compared to an vessel without a barrier coating or layer;

    the pH protective coating or layer comprising SiOxCy wherein x is from about 0.5 to about 2.4 and y is from about 0.6 to about 3, the pH protective coating or layer having an interior surface facing the lumen and an outer surface facing the interior surface of the barrier coating or layer,the combination of the tie coating or layer and the pH protective coating or layer being effective to increase the calculated shelf life of the package (total Si/Si dissolution rate); and

    a fluid composition contained in the lumen and having a pH between 5 and 9;

    wherein the calculated shelf life of the package is more than six months at a storage temperature of 4°

    C.

View all claims
  • 5 Assignments
Timeline View
Assignment View
    ×
    ×