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Pharmaceutical compositions for treating or preventing pain

  • US 10,016,368 B2
  • Filed: 11/08/2016
  • Issued: 07/10/2018
  • Est. Priority Date: 07/08/2009
  • Status: Active Grant
First Claim
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1. A solid oral pharmaceutical composition, wherein the solid oral pharmaceutical composition comprises:

  • (1) a first layer that comprises;

    (a) 5 mg to 30 mg of an antiemetic,(b) about 75 mg to about 150 mg of silicified microcrystalline cellulose,(c) about 10 mg to about 20 mg of croscarmellose sodium, and(d) about 0.5 mg to 2 mg of magnesium stearate; and

    (2) a second layer that comprises;

    (a) about 0.5 mg to about 20 mg of an opioid analgesic,(b) about 75 mg to about 250 mg of silicified microcrystalline cellulose,(c) about 10 mg to about 40 mg of hydroxy methyl propyl cellulose,(d) about 0.5 mg to 5 mg of magnesium stearate, and(e) about 0.5 mg to about 5 mg of stearic acid.

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