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Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects

  • US 10,016,404 B2
  • Filed: 05/25/2017
  • Issued: 07/10/2018
  • Est. Priority Date: 03/05/2004
  • Status: Active Grant
First Claim
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1. A method of treating a human subject suffering from hyperlipidemia or hypercholesterolemia, the method comprising administering to the human subject an effective amount of an MTP inhibitor, the administration of the MTP inhibitor comprising three step-wise, increasing dose levels of the MTP inhibitor, wherein each of the dose levels is no more than 50% of the immediately following dose level;

  • wherein each of the dose levels is administered for about 1 to about 12 weeks;

    wherein the MTP inhibitor is N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4′

    (trifluoromethyl)[1,1′

    -biphenyl]-2-yl] carbonyl] amino]-1-piperidinyl]butyl]-9H-fluorene-9 carboxamide, methanesulfonate; and

    wherein the administration of the MTP inhibitor reduces total cholesterol of the human subject by at least 30% as compared to control blood levels.

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