Alpha-hydroxy carboxylic acid and derivatives and other GRAS based prodrugs of oxycodone and uses thereof

• US 10,017,519 B2
• Filed: 11/29/2015
• Issued: 07/10/2018
• Est. Priority Date: 04/27/2015
• Status: Active Grant

• Current Assignee: 3St Research LLC
• Original Assignee: 3St Research LLC
• Inventors: Thottathil, John K.
• Primary Examiner(s): Anderson, James D.
• Application Number:
  US14/953,392
• Publication Number:
  US 20170152266A1
• Time in Patent Office: 954 Days
• CPC Class Codes: A61P 25/36 Opioid-abuse
• CPC Class Codes: C07D 489/08 Oxygen atom

Abstract

The invention describes pharmaceutical compounds and compositions comprised of a ligand attached to the opioid oxycodone, in a manner that substantially decreases or deters the potential for opioid abuse, addiction, illicit and illegal use, and overdose. When delivered at the proper dosage, the pharmaceutical composition provides therapeutic activity similar to that of the parent active agent.

Claims

1. An oxycodone prodrug compound represented by any one of

2. A pharmaceutical composition comprising one or more of the oxycodone prodrug compounds according to claim 1 and one or more pharmaceutically acceptable excipients.

3. An oral pharmaceutical composition comprising one or more of the the oxycodone prodrug compounds according to claim 1 and one or more pharmaceutically acceptable excipients.

4. The pharmaceutical composition according to claim 3, wherein the compound is a pharmaceutically acceptable salt form.

5. A method of treating pain comprising orally administering the composition according to claim 3 to a patient.

6. The pharmaceutical composition according to claim 2, wherein the compound is a pharmaceutically acceptable salt form.