Methods for reprogramming somatic cells
DC CAFCFirst Claim
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1. A method of making a somatic cell more susceptible to reprogramming to a cell having a less differentiated state, comprising:
- obtaining a somatic cell that comprises an exogenously introduced polynucleic acid encoding Oct4 protein, and an exogenously introduced polynucleic acid encoding Sox2 or Nanog protein;
wherein the exogenously introduced polynucleic acids result in making the somatic cell more susceptible to reprogramming to a less differentiated state.
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Abstract
The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state.
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9 Claims
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1. A method of making a somatic cell more susceptible to reprogramming to a cell having a less differentiated state, comprising:
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obtaining a somatic cell that comprises an exogenously introduced polynucleic acid encoding Oct4 protein, and an exogenously introduced polynucleic acid encoding Sox2 or Nanog protein; wherein the exogenously introduced polynucleic acids result in making the somatic cell more susceptible to reprogramming to a less differentiated state. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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