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Methods and devices for reading microarrays

  • US 10,019,620 B2
  • Filed: 08/25/2017
  • Issued: 07/10/2018
  • Est. Priority Date: 05/22/2009
  • Status: Active Grant
First Claim
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1. A method for improving image flatness of a surface image of a probe array having an array surface roughness, the method comprising:

  • imaging one or more fiducials of the probe array at a plurality of positions along an axis of translation and determining a best position measurement for each of the fiducials at which the imaging is sharpest;

    generating a surface fit profile based on a plurality of the best position measurements; and

    imaging the probe array and adjusting one or more surface non-flatness parameters based on the surface fit profile to improve the image flatness of the surface image of the probe array.

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