Coating method

• US 10,022,322 B2
• Filed: 11/12/2015
• Issued: 07/17/2018
• Est. Priority Date: 12/24/2007
• Status: Active Grant

• Current Assignee: Vaxxas Pty Ltd.
• Original Assignee: Vaxxas Pty Ltd.
• Inventors: Kendall, Mark Anthony Fernance, Fernando, Germain, Chen, Xianfeng, Prow, Tarl
• Primary Examiner(s): Swartz, Rodney P
• Application Number:
  US14/939,726
• Publication Number:
  US 20160058697A1
• Time in Patent Office: 978 Days
• Field of Search: 424 91, 424 92, 604 9301, 604173, 604272
• CPC Class Codes: A61K 39/39 characterised by the immunostimulating additives, e.g. chemical adjuvants
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/0046 Solid microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: B05D 3/0466 the gas being a non-reacting gas B05D3/0406 takes precedence

Abstract

A method of coating a material onto projections provided on a patch. The method includes applying a coating solution containing the material to at least the projections and drying the coating solution to at least the projections using a gas flow.

Claims

1. A microprojection array comprising microprojections coated with a material, wherein the material is coated onto the microprojections by using a gas flow to distribute a coating solution containing the material over the microprojections and using a gas flow to dry the coating solution, and wherein the coating solution has at least one of:

a) a viscosity of between 10<sup>−

3</sup> Pa·

S and 1 Pa·

S; and

b) a surface tension of between 0.023 N/m and 0.073 N/m.

2. A microprojection array according to claim 1, wherein the material includes at least one of:

a) nanoparticles;

b) a nucleic acid or protein;

c) an antigen, allergen, or adjuvant;

d) parasites, bacteria, viruses, or virus-like particles;

e) quantum dots, SERS tags, Raman tags or other nanobiosensors;

f) metals or metallic compounds; and

,

g) molecules, elements or compounds.

3. A microprojection array according to claim 1, wherein the coating solution further includes a therapeutic agent.

4. A microprojection array according to claim 3, wherein the therapeutic agent is at least one of:

a) DNA; and

,

b) protein.

5. A microprojection array according to claim 1, wherein the coating solution includes the material and at least one of:

a) a viscosity enhancer;

b) a surfactant;

or

c) an adjuvant.

6. A microprojection array according to claim 5, wherein at least one of:

a) the viscosity enhancer is 0% to 90% of the coating solution; and

,

b) the surfactant is 0% to 90% of the coating solution.

7. A microprojection array according to claim 5, wherein the viscosity enhancer is methylcellulose (MC), carboxymethylcellulose (CMC), gelatin, agar, agarose or any combination thereof.

8. A microprojection array according to claim 1, wherein the coating solution has a viscosity of 0.01-0.06 Pa·

S.

9. A microprojection array according to claim 1, wherein the coating solution has a surface tension of 0.03-0.04 N/m.

10. A microprojection array according to claim 1, wherein the microprojections are provided on a patch having a surface area of approximately 0.16 cm².

11. A microprojection array according to claim 1, wherein the microprojections have a length of between 10 to 400 μ

m.

12. A microprojection array according to claim 11, wherein the microprojections have a length of 90 μ

m.

13. A microprojection array according to claim 1 wherein the microprojections have a radius of curvature of greater than 1 μ

m.

14. A microprojection array according to claim 13, wherein the microprojections have a radius of curvature greater than 5 μ

m.

15. A microprojection array according to claim 1, wherein the microprojections include a support section and a targeting section.

16. A microprojection array according to claim 1, wherein the microprojections are solid.

17. A microprojection array according to claim 1, wherein the microprojections are non-porous and non-hollow.

18. A microprojection array according to claim 1, wherein the microprojection array is one of:

a) hydrophobic; and

,

b) hydrophilic.

19. A microprojection array comprising microprojections coated with a material, wherein the material is coated onto the microprojections by using a gas flow to distribute a coating solution containing the material over the microprojections and using a gas flow to dry the coating solution, wherein the coating solution includes die material and at least one of a viscosity enhancer, a surfactant or an adjuvant, and wherein at least one of:

a) the viscosity enhancer is 0% to 90% of the coating solution; and

,

b) the surfactant is 0% to 90% of the coating solution.

20. A microprojection array comprising microprojections coated with a material, wherein the material is coated onto the microprojections by using a gas flow to distribute a coating solution containing the material over the microprojections and using a gas flow to dry the coating solution, wherein the coating solution includes the material and at least one of a viscosity enhancer, a surfactant or an adjuvant, and wherein the viscosity enhancer is methylcellulose (MC), carboxymethylcellulose (CMC), gelatin, agar, agarose or any combination thereof.

21. A microprojection array comprising microprojections coated with a material, wherein the material is coated onto the microprojections by using a gas flow to distribute a coating solution containing the material over the microprojections and using a gas flow to dry the coating solution, and wherein the microprojections are provided on a patch having a surface area of approximately 0.16 cm².

22. A microprojection array comprising microprojections coated with a material, wherein the material is coated onto the microprojections by using a gas flow to distribute a coating solution containing the material over the microprojections and using a gas flow to dry the coating solution, and wherein the microprojections have a radius of curvature of greater than 1 μ

m.

23. A microprojection array comprising microprojections coated with a material, wherein the material is coated onto the microprojections by using a gas flow to distribute a coating solution containing the material over the microprojections and using a gas flow to dry the coating solution, and wherein the microprojections include a support section and a targeting section.