Methods for treating spinal cord injury
First Claim
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1. A method for treating a spinal cord injury in a subject by promoting axon regeneration in a Central Nervous System (CNS) neuron, the method comprising:
- exposing the CNS neuron of the subject to an effective amount of a necrostatin and an effective amount of an apoptosis inhibitor thereby to promote the regeneration of the axon of the CNS neuron;
wherein the necrostatin is selected from the group consisting of;
(i) a Nec-1 related compound of Formula I;
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Abstract
Provided are methods for promoting axon regeneration of a Central Nervous System (CNS) neuron and promoting nerve function following injury to a CNS neuron, for example, brain and/or spinal cord injury. Axon regeneration in a CNS neuron or nerve function following injury to a CNS neuron can be promoted by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject suffering from a CNS disorder, wherein a symptom of the CNS disorder is axon degeneration.
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Citations
12 Claims
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1. A method for treating a spinal cord injury in a subject by promoting axon regeneration in a Central Nervous System (CNS) neuron, the method comprising:
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exposing the CNS neuron of the subject to an effective amount of a necrostatin and an effective amount of an apoptosis inhibitor thereby to promote the regeneration of the axon of the CNS neuron; wherein the necrostatin is selected from the group consisting of; (i) a Nec-1 related compound of Formula I; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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