Lipid-encapsulated gas microsphere compositions and related methods
First Claim
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1. A composition of an ultrasound contrast agent comprisinga non-aqueous mixture comprising DPPA, DPPC and MPEG5000-DPPE in propylene glycol and/or glycerol, anda perfluorocarbon gas,wherein the non-aqueous mixture comprises less than 5% w/w (weight/weight) water,and wherein DPPA, DPPC and MPEG5000-DPPE are present in a ratio of about 10:
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8 (mole %).
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Abstract
The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.
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Citations
24 Claims
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1. A composition of an ultrasound contrast agent comprising
a non-aqueous mixture comprising DPPA, DPPC and MPEG5000-DPPE in propylene glycol and/or glycerol, and a perfluorocarbon gas, wherein the non-aqueous mixture comprises less than 5% w/w (weight/weight) water, and wherein DPPA, DPPC and MPEG5000-DPPE are present in a ratio of about 10:
Specification