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Lipid-encapsulated gas microsphere compositions and related methods

  • US 10,022,460 B2
  • Filed: 05/23/2017
  • Issued: 07/17/2018
  • Est. Priority Date: 12/31/2014
  • Status: Active Grant
First Claim
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1. A composition of an ultrasound contrast agent comprisinga non-aqueous mixture comprising DPPA, DPPC and MPEG5000-DPPE in propylene glycol and/or glycerol, anda perfluorocarbon gas,wherein the non-aqueous mixture comprises less than 5% w/w (weight/weight) water,and wherein DPPA, DPPC and MPEG5000-DPPE are present in a ratio of about 10:

  • 82;

    8 (mole %).

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