Manifolds for use in conducting dialysis

• US 10,022,673 B2
• Filed: 04/28/2016
• Issued: 07/17/2018
• Est. Priority Date: 09/25/2007
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Original Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Inventors: Fulkerson, Barry Neil, Joseph, Russell T.
• Primary Examiner(s): Menon, Krishnan S
• Application Number:
  US15/141,464
• Publication Number:
  US 20170021306A1
• Time in Patent Office: 810 Days
• Field of Search: None
• CPC Class Codes: A61M 1/1692 Detection of blood traces in dialysate
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/3413 Diafiltration
• CPC Class Codes: A61M 1/3639 Blood pressure control, pressure transducers specially adapted therefor
• CPC Class Codes: A61M 2205/126 with incorporated membrane filters
• CPC Class Codes: A61M 2205/3553 remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: B01D 2313/10 Specific supply elements
• CPC Class Codes: B01D 2313/105 Supply manifolds
• CPC Class Codes: B01D 2313/12 Specific discharge elements
• CPC Class Codes: B01D 2313/125 Discharge manifolds
• CPC Class Codes: B01D 2313/243 Pumps
• CPC Class Codes: B01D 61/145 Ultrafiltration
• CPC Class Codes: B01D 61/18 Apparatus therefor
• CPC Class Codes: B01D 61/30 Accessories; Auxiliary operation
• CPC Class Codes: Y10T 137/8158 With indicator, register, recorder, alarm or inspection means
• CPC Class Codes: Y10T 137/87153 Plural noncommunicating flow paths
• CPC Class Codes: Y10T 137/87249 Multiple inlet with multiple outlet

Abstract

The present application discloses novel systems for conducting the filtration of blood using manifolds. The manifolds integrate various sensors and have fluid pathways formed therein to direct fluids from various sources through the requisite blood filtration or ultrafiltration system steps.

Claims

1. A disposable apparatus for use in filtering blood comprising:

a molded plastic substrate having a first flow path and a second flow path formed therein, wherein the first flow path and second flow path are fluidically isolated from each other, wherein the molded plastic substrate comprises a plurality of concave spaces;

a hemofilter cartridge positioned within a first of the plurality of concave spaces and in fluid communication with the first flow path and the second flow path;

at least one sensor positioned within a second of the plurality of concave spaces;

a plurality of ports integrated into the molded plastic substrate; and

embedded data, wherein the embedded data uniquely identifies the disposable apparatus and wherein the disposable apparatus is caused to be unusable based on the embedded data.

2. The disposable apparatus of claim 1 further comprising tubing having a first end fixedly attached to at least one of the ports and a second end fixedly attached to an input port of a dialyzer.

3. The disposable apparatus of claim 1 further comprising tubing having a first end fixedly attached to at least one of the ports and a second end adapted to be removably attached to an input port of a collection reservoir.

4. The disposable apparatus of claim 3 further comprising tubing having a first end fixedly attached to at least one of the ports and a second end adapted to be removably attached to an input port of a dialysate regeneration system.

5. The disposable apparatus of claim 1 further comprising a first tubing having a first end fixedly attached to a first one of the ports and a second end fixedly attached to an input port of a dialyzer and a second tubing having a first end fixedly attached to a second one of the ports and a second end fixedly attached to an output port of the dialyzer.

6. A disposable apparatus for use in filtering blood comprising:

a plastic substrate comprising a plurality of molded concave spaces;

first and second inlet ports positioned in the plastic substrate;

first and second outlet ports positioned in the plastic substrate;

a first flow path formed in the plastic substrate wherein the first flow path forms a pathway for transporting blood from the first inlet port to the first outlet port;

a first sensor positioned directly in the first flow path;

a second flow path formed in the plastic substrate wherein the second flow path forms a pathway for transporting a first fluid from the second inlet port to the second outlet port;

a second sensor positioned directly in the second flow path;

a hemofilter cartridge positioned within a first of the plurality of concave spaces and in fluid communication with the first flow path and the second flow path; and

embedded data, wherein the embedded data uniquely identifies the disposable apparatus and wherein the disposable apparatus is caused to be unusable based on the embedded data.

7. The disposable apparatus of claim 6 further comprising tubing having a first end fixedly attached to the first inlet port and a second end fixedly attached to an output port of a dialyzer.

8. The disposable apparatus of claim 6 further comprising tubing having a first end fixedly attached to the second outlet port and a second end adapted to be removably attached to an input port of a collection reservoir.

9. The disposable apparatus of claim 6 further comprising:

a third inlet port;

a third outlet port; and

a third flow path formed in the plastic substrate comprising at least one sensor directly molded therein wherein the third flow path forms a pathway for transporting blood from the third inlet port to the third outlet port.

10. The disposable apparatus of claim 9 further comprising tubing having a first end fixedly attached to the third outlet port and a second end adapted to be removably attached to an input port of a dialysate regeneration system.

11. The disposable apparatus of claim 6 wherein the sensor comprises a transducer diaphragm.

12. The disposable apparatus of claim 11 wherein the transducer diaphragm comprises polyisoprene.

13. A disposable apparatus for use in filtering blood comprising:

a molded plastic substrate having a first flow path and a second flow path formed therein, wherein the first flow path and second flow path are fluidically isolated from each other, wherein the molded plastic substrate comprises a plurality of spaces;

a plurality of ports integrated into the molded plastic substrate;

a hemofilter cartridge positioned within a first of the plurality of spaces and in fluid communication with the first flow path and the second flow path;

a plurality of interfacing components, each of the interfacing components configured to have at least 5 pounds of strength and a seal up to 600 mmHg; and

embedded data, wherein the embedded data uniquely identifies the disposable apparatus and wherein the disposable apparatus is caused to be unusable based on the embedded data.

14. The disposable apparatus of claim 13 wherein the sensor comprises a transducer diaphragm.

15. The disposable apparatus of claim 13 further comprising tubing having a first end fixedly attached to at least one of the ports and a second end fixedly attached to an input port of a dialyzer.

16. The disposable apparatus of claim 13 further comprising tubing having a first end fixedly attached to at least one of the ports and a second end adapted to be removably attached to an input port of a collection reservoir.

17. The disposable apparatus of claim 13 further comprising tubing having a first end fixedly attached to at least one of the ports and a second end adapted to be removably attached to an input port of a dialysate regeneration system.

18. The disposable apparatus of claim 13 further comprising a first tubing having a first end fixedly attached to a first one of the ports and a second end fixedly attached to an input port of a dialyzer and a second tubing having a first end fixedly attached to a second one of the ports and a second end fixedly attached to an output port of the dialyzer.