Sample vessels

• US 10,022,722 B2
• Filed: 04/01/2015
• Issued: 07/17/2018
• Est. Priority Date: 06/24/1998
• Status: Expired due to Term

• Current Assignee: Roche Molecular Systems Inc (Roche Holding AG)
• Original Assignee: Roche Molecular Systems Inc (Roche Holding AG)
• Inventors: Chen, Shuqi, Chen, Lingjun
• Primary Examiner(s): Warden, Jill A
• Assistant Examiner(s): FISHER, BRITTANY I
• Application Number:
  US14/676,662
• Publication Number:
  US 20150375225A1
• Time in Patent Office: 1,203 Days
• Field of Search: None
• CPC Class Codes: A61B 5/1427 Multiple blood sampling, e.g. at periodic or pre-established intervals
• CPC Class Codes: A61B 5/1438 using pre-evacuated means
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150221 Valves
• CPC Class Codes: A61B 5/150251 Collection chamber divided into at least two compartments, e.g. for division of samples injection syringes having more than one chamber A61M5/19; syringes for injection of two or more media A61M5/2448, A61M5/284; sample preparation for further analysis A61B5/150755
• CPC Class Codes: A61B 5/150259 Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
• CPC Class Codes: A61B 5/150351 Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel caps for bottles or containers in general B65D41/00
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150389 Hollow piercing elements, e.g. canulas, needles, for piercing the skin
• CPC Class Codes: A61B 5/150488 Details of construction of shaft
• CPC Class Codes: A61B 5/150717 manually removed
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/150786 Optical identification systems, e.g. bar codes, colour codes
• CPC Class Codes: B01L 2200/026 Fluid interfacing between devices or objects, e.g. connectors, inlet details
• CPC Class Codes: B01L 2300/021 Identification, e.g. bar codes
• CPC Class Codes: B01L 2300/044 pierceable, e.g. films, membranes
• CPC Class Codes: B01L 2300/046 Function or devices integrated in the closure
• CPC Class Codes: B01L 2300/047 Additional chamber, reservoir
• CPC Class Codes: B01L 2300/0636 Integrated biosensor, microarrays
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0832 : cylindrical, tube shaped
• CPC Class Codes: B01L 2300/0887 : Laminated structure
• CPC Class Codes: B01L 2300/123 : Flexible; Elastomeric
• CPC Class Codes: B01L 2400/0481 : squeezing of channels or chambers
• CPC Class Codes: B01L 2400/0655 : pinch valves
• CPC Class Codes: B01L 2400/0694 : vents used to stop and induce flow, backpressure valves
• CPC Class Codes: B01L 3/502 : with fluid transport, e.g. in multi-compartment structures centrifugal-type cuvettes G01N21/07; analysis by separation into components G01N30/00; automatic analysers G01N35/00
• CPC Class Codes: B01L 3/5027 : by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: B01L 3/505 : flexible containers not provided for above
• CPC Class Codes: B01L 3/50825 : Closing or opening means, corks, bungs closures for containers B65D; means for removing stoppers B67B7/02

Abstract

A sample vessel may include a segmented tubule having an opening for receiving a sample material and at least one compressible section, the at least one compressible section having a wall constructed at least partially from a material having sufficient flexibility to permit compression of opposed sections of the wall into contact, and at least two segments of the tubule being fluidically isolated from one another by a bonding of opposed sections of the tubule wall to one another. The sample vessel may also include an interface in fluid communication with the opening in the tubule, the interface facilitating delivery of a sample material to the tubule through the opening.

Claims

1. A sample vessel comprising:

a sample tubule having a plurality of lumens and walls that oppose one another having at least one compressible section, the at least one compressible section having a wall constructed at least partially from a material having sufficient flexibility to permit compression of opposed sections of the wall into contact with one another, wherein at least two lumens of the plurality of lumens are connected by a first pressure gate that permits selective fluid flow between the at least two lumens;

a reservoir configured to contain fluid delivered from an external device;

a second pressure gate that provides a fluid channel to permit selective displacement of a fluid between the tubule and the reservoir; and

a third pressure gate that provides a fluid channel to permit selective displacement of a fluid between the external device and the reservoir.

2. The sample vessel of claim 1, wherein the external device is a needle.

3. The sample vessel of claim 2, wherein reservoir comprises a membrane configured to be penetrated by the needle to deliver fluid to the reservoir.

4. The sample vessel of claim 3, wherein the membrane is a self-sealing membrane.

5. The sample vessel of claim 1, wherein one or more of the first, second or third pressure gates are reversible or irreversible.