Portable blood count monitor
First Claim
Patent Images
1. A device comprising:
- a) a slide configured to receive a body fluid, wherein the slide comprises;
i) a first chamber, wherein the first chamber contains a first reagent that detects a red blood cell in the body fluid by sphering the red blood cell; and
ii) a second chamber, wherein the second chamber contains a second reagent that differentiates a white blood cell in the body fluid from the red blood cell,wherein the first chamber and the second chamber are connected by a fluidic channel; and
b) an imaging system that acquires an image of the red blood cell from the first chamber and an image of the white blood cell from the second chamber of the slide.
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Abstract
This disclosure describes the development of a sample preparation, measurement, and analysis method that permits accurate characterization of red blood cells, platelets, and white blood cells, including a 3-part differential of the white blood cells count, to be performed on small volumes of a biological sample. This method is compatible with compact and portable instrumentation that permits the sample collection to be performed in a subject'"'"'s home and analysis to be performed elsewhere by transmission of the data to a laboratory or doctor'"'"'s office.
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Citations
63 Claims
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1. A device comprising:
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a) a slide configured to receive a body fluid, wherein the slide comprises; i) a first chamber, wherein the first chamber contains a first reagent that detects a red blood cell in the body fluid by sphering the red blood cell; and ii) a second chamber, wherein the second chamber contains a second reagent that differentiates a white blood cell in the body fluid from the red blood cell, wherein the first chamber and the second chamber are connected by a fluidic channel; and b) an imaging system that acquires an image of the red blood cell from the first chamber and an image of the white blood cell from the second chamber of the slide. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A device comprising:
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a) a slide configured to receive a body fluid, wherein the slide comprises a first chamber and a second chamber, wherein the first chamber contains a first reagent that spheres a red blood cell in the body fluid, and the second chamber contains a second reagent that differentiates a white blood cell in the body fluid from the red blood cell; b) an imaging system that acquires an image of the red blood cell from the first chamber and an image of the white blood cell from the second chamber of the slide; and c) a transmitter configured to wirelessly-transmit the image of the red blood cell from the first chamber and the image of the white blood cell from the second chamber of the slide over a distance of at least one mile. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A method for analyzing a body fluid, the method comprising:
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a) providing the body fluid to a slide, wherein the slide comprises a first chamber and a second chamber, wherein the first chamber and the second chamber are connected by a fluidic channel; b) detecting in the first chamber a red blood cell in the body fluid with a first reagent that spheres the red blood cell; c) detecting in the second chamber a white blood cell in the body fluid with a second reagent that differentiates the white blood cell in the body fluid from the red blood cell; and d) acquiring by an imaging system an image of the red blood cell from the first chamber and an image of the white blood cell from the second chamber of the slide. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. A system comprising:
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a) a device comprising; i) a slide configured to receive a body fluid, wherein the slide comprises a first chamber that contains a first reagent that spheres a red blood cell and a second chamber that contains a second reagent that differentiates a white blood cell in the body fluid from the red blood cell, wherein the first chamber and the second chamber are connected by a fluidic channel; ii) an imaging system that acquires an image of the red blood cell from the first chamber and an image of the white blood cell from the second chamber of the slide; and iii) a transmitter, wherein the transmitter wirelessly transmits the image from the first chamber and the image from the second chamber; and b) a receiver that receives the wirelessly-transmitted image from the first chamber and the wirelessly-transmitted image from the second chamber from the transmitter, wherein the transmitter and the receiver are configured to communicate over a distance of at least 1 mile. - View Dependent Claims (41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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51. A kit comprising:
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a) a device comprising; i) a slide configured to receive a body fluid, wherein the slide comprises a first chamber and a second chamber, wherein the first chamber and the second chamber are connected by a fluidic channel; and ii) an imaging system that acquires an image of a red blood cell from the first chamber and an image of a white blood cell from the second chamber of the slide; b) a first reagent that spheres the red blood cell in the body fluid in the first chamber; and c) a second reagent that differentiates the white blood cell in the body fluid from the red blood cell in the second chamber. - View Dependent Claims (52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63)
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Specification