Particle-containing membrane and particulate electrode for analyte sensors

• US 10,028,683 B2
• Filed: 10/07/2014
• Issued: 07/24/2018
• Est. Priority Date: 09/19/2008
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Simpson, Peter C., Boock, Robert J., Wightlin, Matthew D., Shults, Mark C.
• Primary Examiner(s): JANG, CHRISTIAN YONGKYUN
• Application Number:
  US14/508,990
• Publication Number:
  US 20150025346A1
• Time in Patent Office: 1,386 Days
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6848 Needles

Abstract

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

Claims

1. A system for continuous in vivo measurement of glucose in a host, the system comprising:

a continuous glucose sensor configured for implantation in a host and configured to measure in vivo a signal indicative of a glucose concentration, wherein the continuous glucose sensor comprises an electrode, wherein the electrode comprises a glucose-impermeable material and conductive particles distributed within the glucose-impermeable material, wherein each of the conductive particles has a three-dimensional electroactive surface;

a biocompatible membrane located over at least a portion of the electrode, wherein the biocompatible membrane is configured to reduce a flux of glucose therethrough; and

sensor electronics operably connected to the continuous glucose sensor, wherein the sensor electronics are configured to process the signal from the continuous glucose sensor.

2. The system of claim 1, wherein the electrode comprises a plurality of sensing elements, wherein the sensor electronics are configured to determine the glucose concentration by averaging or integrating signals from the plurality of sensing elements.

3. The system of claim 1, wherein the electroactive surfaces all have a substantially equal area.

4. The system of claim 1, wherein the electroactive surfaces are each spaced apart from at least one adjacent electroactive surface by a substantially equal distance.

5. The system of claim 1, wherein the biocompatible membrane comprises polyurethane.

6. The system of claim 1, wherein the continuous glucose sensor has a planar shape.

7. The system of claim 1, wherein the electrode comprises a mixture comprising of metal oxide and carbon.

8. The system of claim 7, wherein the mixture further comprises platinum.

9. The system of claim 1, wherein the sensor is configured to apply a bias potential from about 0.1 V to about 0.6 V.

10. The system of claim 9, wherein the sensor is configured to apply a bias potential at around 0.35 V.

11. The system of claim 2, wherein the sensing elements are spaced along a substantial length of an in vivo portion of the continuous glucose sensor.

12. The system of claim 2, wherein the plurality of sensing elements comprise more than two electroactive surfaces.

13. The system of claim 2, wherein the plurality of sensing elements comprise more than three electroactive surfaces.

14. The system of claim 2, wherein the plurality of sensing elements are spaced apart within a diffusion distance of a measured glucose.