Methods for generating hybrid analyte level output, and devices and systems related thereto

• US 10,028,686 B2
• Filed: 03/22/2016
• Issued: 07/24/2018
• Est. Priority Date: 06/30/2011
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories)
• Inventors: Hayter, Gary A.
• Primary Examiner(s): BLOCH, MICHAEL RYAN
• Application Number:
  US15/077,520
• Publication Number:
  US 20160262669A1
• Time in Patent Office: 854 Days
• Field of Search: None
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes

Abstract

Generally, methods, devices, and systems for generating a hybrid analyte level output are provided. The uncompensated analyte levels lag in time with respect to the lag-compensated analyte levels, and the hybrid analyte level output tracks between the uncompensated analyte levels and the lag-compensated analyte levels according to predetermined criteria.

Claims

1. A method of generating a hybrid analyte level output, comprising:

receiving continuous sensor data comprising uncompensated analyte levels received from an in vivo sensor, the uncompensated analyte levels comprising interstitial fluid glucose levels;

deriving lag-compensated analyte levels from the uncompensated analyte levels using a processor, the lag-compensated analyte levels comprising estimated blood glucose levels; and

generating the hybrid analyte level output comprised of the uncompensated analyte levels and the lag-compensated analyte levels using the processor, wherein the uncompensated analyte levels lag in time with respect to the lag-compensated analyte levels;

wherein the hybrid analyte level output tracks between the uncompensated analyte levels and the lag-compensated analyte levels according to predetermined criteria, the predetermined criteria comprising;

criteria for tracking the uncompensated analyte levels when selected analyte levels are below a predetermined threshold and have been rising for at least a predetermined duration of time; and

criteria for tracking the lag-compensated analyte levels when the selected analyte levels are not below the predetermined threshold or have not been rising for at least the predetermined duration of time.

2. The method of claim 1, wherein the selected analyte levels comprise at least one selected from the group consisting of most recently derived lag-compensated analyte levels and most recently received uncompensated analyte levels.

3. The method of claim 1, wherein the generating comprises:

transitioning from the uncompensated analyte levels to the lag-compensated analyte levels and wherein the hybrid analyte level output comprises weighted combinations of the uncompensated analyte levels and the lag-compensated analyte levels when transitioning from the uncompensated analyte levels to the lag-compensated analyte levels; and

/or

transitioning from the lag-compensated analyte levels to the uncompensated analyte levels and wherein the hybrid analyte level output comprises weighted combinations of the uncompensated analyte levels and the lag-compensated analyte levels when transitioning from the lag-compensated analyte levels to the uncompensated analyte levels.

4. The method of claim 1, wherein the predetermined criteria further comprises criteria for tracking the lag-compensated analyte levels until the hybrid analyte level output falls below a second predetermined threshold, wherein the hybrid analyte level output tracks a lower of the lag-compensated analyte level and the uncompensated analyte level when the hybrid analyte level output falls below the second predetermined threshold.

5. The method of claim 1, wherein deriving the lag-compensated analyte levels comprises applying a lag compensation filter to the uncompensated analyte levels.

6. The method of claim 1, comprising audibly or visually outputting the hybrid analyte level output on a user interface.

7. The method of claim 1, comprising:

audibly or visually outputting the lag-compensated analyte levels on a user interface; and

indicating a low analyte level with the user interface when the lag-compensated analyte levels falls below a predetermined low-entering threshold value.

8. The method of claim 7, comprising:

removing the indication of the low analyte level when a predetermined low-exiting threshold value is exceeded by at least one signal selected from the group consisting of the lag-compensated analyte levels, the uncompensated analyte levels, and the hybrid analyte level output.

9. The method of claim 1, wherein the predetermined threshold comprises a glucose value that indicates hypoglycemia.

10. An analyte monitoring device, comprising:

a processor; and

non-transitory memory operably coupled to the processor, the non-transitory memory including instructions stored therein that, when executed by the processor, cause the processor to;

receive continuous sensor data, comprising uncompensated analyte levels received from an in vivo sensor, the uncompensated analyte levels comprising interstitial fluid glucose levels;

derive lag-compensated analyte levels from the uncompensated analyte levels, the lag-compensated analyte levels comprising estimated blood glucose levels; and

generate a hybrid analyte level output comprised of the uncompensated analyte levels and the lag-compensated analyte levels, wherein the uncompensated analyte levels lag in time with respect to the lag-compensated analyte levels;

wherein the hybrid analyte level output tracks between the uncompensated analyte levels and the lag-compensated analyte levels according to predetermined criteria, the predetermined criteria comprising;

criteria for tracking the uncompensated analyte levels when selected analyte levels are below a predetermined threshold and have been rising for at least a predetermined duration of time; and

criteria for tracking the lag-compensated levels when the selected analyte levels are not below the predetermined threshold or have not been rising for at least the predetermined duration of time.

11. The analyte monitoring device of claim 10, wherein the selected analyte levels comprise at least one selected from the group consisting of most recently derived lag-compensated analyte levels and most recently received uncompensated analyte levels.

12. The analyte monitoring device of claim 10, wherein the hybrid analyte level output transitions from:

the uncompensated analyte levels to the lag-compensated analyte levels and comprises weighted combinations of the uncompensated analyte levels and the lag-compensated analyte levels; and

/or

the lag-compensated analyte levels to the uncompensated analyte levels and comprises weighted combinations of the uncompensated analyte levels and the lag-compensated analyte levels.

13. The analyte monitoring device of claim 10, wherein the predetermined criteria further comprises criteria for tracking the lag-compensated analyte level until the hybrid analyte level output falls below a second predetermined threshold, wherein the hybrid analyte level output tracks a lower of the lag-compensated analyte level and the uncompensated analyte level when the hybrid analyte level output falls below the second predetermined threshold.

14. The analyte monitoring device of claim 10, wherein a lag compensation filter is applied to the uncompensated analyte levels to derive the lag-compensated analyte levels.

15. The analyte monitoring device of claim 10, further comprising a user interface, wherein the non-transitory memory includes instructions stored therein that, when executed by the processor, cause the processor to audibly or visually output the hybrid analyte level output on the user interface of the analyte monitoring device.

16. An analyte monitoring system, comprising:

an on-body unit, comprising;

a first processor and first non-transitory memory operably coupled to the first processor;

an in vivo sensor operably coupled to the first processor; and

a receiver configured to communicate with the on-body unit, the receiver comprising;

a second processor and second non-transitory memory operably coupled to the second processor, wherein at least one of the first non-transitory memory and second non-transitory memory includes instructions stored therein that, when executed by at least one of the first processor and second processor, cause the at least one first processor and second processor to;

receive continuous sensor data comprising uncompensated analyte levels received from the in vivo sensor, the uncompensated analyte levels comprising interstitial fluid glucose levels;

derive lag-compensated analyte levels from the uncompensated analyte levels, the lag-compensated analyte levels comprising estimated blood glucose levels; and

generate a hybrid analyte level output comprised of uncompensated analyte levels and lag-compensated analyte levels, wherein the uncompensated analyte levels lag in time with respect to the lag-compensated analyte levels;

wherein the hybrid analyte level output tracks between the uncompensated analyte levels and the lag-compensated analyte levels according to predetermined criteria, the predetermined criteria comprising;

criteria for tracking the uncompensated analyte levels when selected analyte levels are below a predetermined threshold and have been rising for at least a predetermined duration of time; and

criteria for tracking the lag-compensated analyte levels when the selected analyte levels are not below the predetermined threshold or have not been rising for at least the predetermined duration of time.

17. The analyte monitoring system of claim 16, wherein the selected analyte levels comprise at least one selected from the group consisting of most recently derived lag-compensated analyte levels and most recently received uncompensated analyte levels.

18. The analyte monitoring system of claim 16, wherein the hybrid analyte level output transitions from:

the uncompensated analyte levels to the lag-compensated analyte levels and comprises weighted combinations of the uncompensated analyte levels and the lag-compensated analyte levels; and

/or

the lag-compensated analyte levels to the lag-compensated analyte levels and comprises weighted combinations of the uncompensated analyte levels and the lag-compensated analyte levels.

19. The analyte monitoring system of claim 16, wherein the predetermined criteria further comprises criteria for tracking the lag-compensated analyte level until the hybrid analyte level output falls below a second predetermined threshold, wherein the hybrid analyte level output tracks a lower of the lag-compensated analyte level and the uncompensated analyte level when the hybrid analyte level output falls below the second predetermined threshold.

20. The analyte monitoring system of claim 16, wherein the predetermined threshold comprises a glucose value that indicates hypoglycemia.