System for processing physiological data

• US 10,028,706 B2
• Filed: 05/17/2016
• Issued: 07/24/2018
• Est. Priority Date: 11/03/2009
• Status: Active Grant

• Current Assignee: VivaQuant LLC
• Original Assignee: VivaQuant LLC
• Inventors: Brockway, Marina, Brockway, Brian
• Primary Examiner(s): GETZOW, SCOTT M
• Application Number:
  US15/156,523
• Publication Number:
  US 20160256112A1
• Time in Patent Office: 798 Days
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0015 characterised by features of the telemetry system
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/259 using conductive adhesive means, e.g. gels
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/6801 specially adapted to be attached to or worn on the body surface
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal

Abstract

Physiological signals such as ECG signals are obtained from a patient. In accordance with one or more embodiments, an apparatus, system and/or method is directed to process the digitized ECG signals (e.g., by removing noise).

Claims

1. A method comprising:

generating a denoised ECG signal from a digitized ECG signal by reducing in-band noise to provide the denoised ECG signal having, relative to the digitized ECG signal, an improved signal to noise ratio of at least 15 dB as measured by the ANSI/AAMI EC57;

1998 with a quality of signal reconstruction of greater than 95%.

2. The method of claim 1,

further including sampling each digitized ECG signal at 300 Hz or less, and

wherein generating the denoised ECG signal includes reducing in-band noise in the ECG signal using an average power consumption that is less than 500 micro-Watts per ECG signal.

3. The method of claim 1, further including amplifying the digitized ECG signal, wherein generating the denoised ECG signal includes generating the denoised ECG signal from the amplified digitized ECG signal.

4. The method of claim 1, further including:

obtaining the digitized ECG signal from a subject via at least two ECG leads,

generating a trigger alarm in response to determining that one of the at least two ECG leads is disconnected, and

communicating the trigger alarm to at least one of the subject and a wireless communication circuit.

5. The method of claim 1, wherein generating the denoised ECG signal includes generating the denoised ECG signal in a circuit, further including:

obtaining the digitized ECG signal from a subject via at least two ECG leads,

determining whether the at least two ECG leads are disconnected from the subject,

in response to determining that the at least two leads are disconnected from the subject, operating the circuit in a low-power mode.

6. The method of claim 1, wherein generating the denoised ECG signal includes generating the denoised ECG signal in a computing circuit.

7. The method of claim 1,

wherein digitizing the ECG signal includes digitizing an ECG signal obtained from a patient via at least two ECG sensing electrodes, and generating the denoised ECG signal, using a digitizing circuit and a computing circuit that are housed within a housing, and

further including mechanically fastening the housing to a first one of the ECG sensing electrodes that is adhered to the patient, and electrically coupling the first one of the ECG sensing electrodes to the digitizing circuit.

8. The method of claim 7, further including electrically coupling a second one of the ECG sensing electrodes to the digitizing circuit via a flexible insulated lead wire.

9. A method comprising:

providing a digitized ECG signal with a signal to noise ratio of 0 dB by adding white noise to a relative clean ECG signal as prescribed by the ANSI/AAMI EC57 standard; and

generating a denoised ECG signal from the digitized ECG signal, the denoised ECG signal having, relative to the digitized ECG signal, an improved signal to noise ratio of at least 15 dB as measured by the ANSI/AAMI EC57;

1998 with a quality of signal reconstruction of greater than 95%.

10. An apparatus comprising:

an input port; and

a computing circuit configured and arranged to generate a denoised ECG signal by reducing in-band noise in a digitized ECG signal received via the input port, the denoised ECG signal having, relative to the digitized ECG signal, an improved signal to noise ratio of at least 15 dB as measured by the ANSI/AAMI EC57;

1998 with a quality of signal reconstruction of greater than 95%.

11. The apparatus of claim 10, wherein the computing circuit is configured and arranged to generate the denoised ECG signal from a digitized ECG signal that has a signal to noise ratio of 0 dB computed by adding white noise to a relative clean ECG signal as prescribed by the ANSI/AAMI EC57 standard.

12. The apparatus of claim 10, wherein the computing circuit is configured and arranged to:

sample each digitized ECG signal at 300 Hz or less, and

generate the denoised ECG signal by reducing in-band noise in the ECG signal using an average power consumption that is less than 500 micro-Watts per ECG signal.

13. The apparatus of claim 10, further including an amplifier configured and arranged to amplify the digitized ECG signal, wherein the computing circuit is configured and arranged to generate the denoised ECG signal from the amplified digitized ECG signal.

14. The apparatus of claim 10, further including a digitizing circuit and at least two ECG leads, the digitizing circuit being configured and arranged to generate the digitized ECG signal from an ECG signal obtained from a subject via the at least two ECG leads, wherein the computing circuit is configured and arranged to:

generate a trigger alarm in response to determining that one of the at least two ECG leads is disconnected, and

communicate the trigger alarm to at least one of the subject and a wireless communication circuit.

15. The apparatus of claim 10, further including a digitizing circuit and at least two ECG leads, the digitizing circuit being configured and arranged to generate the digitized ECG signal from an ECG signal obtained from a subject via the at least two ECG leads, wherein the computing circuit is configured and arranged to:

determine whether the at least two ECG leads are disconnected from the subject; and

in response to determining that the at least two leads are disconnected from the subject, operating the circuit in a low-power mode.

16. The apparatus of claim 10, further including:

a digitizing circuit configured and arranged to provide the digitized ECG signal by digitizing an ECG signal obtained from a patient via at least two ECG sensing electrodes;

a housing that houses the digitizing circuit and the computing circuit; and

a mechanical fastener configured and arranged to fasten the housing to a first one of the ECG sensing electrodes that is adhered to the patient and to electrically couple the first one of the ECG sensing electrodes to the digitizing circuit.

17. The apparatus of claim 16, further including a flexible insulated lead wire configured and arranged to couple a second one of the ECG sensing electrodes to the digitizing circuit.

18. An apparatus comprising:

an input port; and

a computing circuit configured and arranged to generate a denoised ECG signal from a digitized ECG signal received via the input port, the denoised ECG signal having, relative to the digitized ECG signal, an improved signal to noise ratio of at least 15 dB as measured by the ANSI/AAMI EC57;

1998 with a quality of signal reconstruction of greater than 95%, by

decomposing the digitized ECG signal into subcomponents;

identifying a first time window in the cardiac cycle that includes a QRS complex;

identifying at least one time window in the cardiac cycle that does not include the QRS complex;

for each of the identified time windows, identifying target subcomponents as subcomponents that contain more energy that is within the band of frequencies characteristic of a desired ECG signal than energy that is outside the band of frequencies of the desired ECG signal; and

constructing a denoised ECG signal using at least two of the identified target subcomponents.

19. The apparatus of claim 18, wherein the computing circuit is configured and arranged to:

compute a statistical variance of the subcomponents over a time interval; and

determine if one of at least two ECG leads that obtain the ECG signal from a patient is disconnected from the patient based upon the statistical variance of the subcomponents.

20. An apparatus comprising:

an ECG electrode configured and arranged to adhere to a patient and to obtain ECG signals from the patient;

a digitizing circuit configured and arranged to digitize the ECG signals;

a computing circuit and configured and arranged to denoise the digitized ECG signals by reducing in-band noise to provide an improved signal to noise ratio of at least 15 dB as measured by ANSI/AAMI EC57;

1998 with a quality of signal reconstruction of greater than 95%; and

a housing that houses the digitizing circuit and the computing circuit, the housing being configured and arranged for coupling to the ECG electrode while the ECG electrode is adhered to the patient, and being configured and arranged with the ECG electrode to fully support the weight of the housing and its contents while the ECG electrode is adhered to and obtaining the ECG signals from the patient.