Coatings for controlling erosion of a substrate of an implantable medical device

• US 10,028,851 B2
• Filed: 06/30/2005
• Issued: 07/24/2018
• Est. Priority Date: 04/15/1997
• Status: Active Grant

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Dugan, Steve, Gale, David C.
• Primary Examiner(s): OU, JING RUI
• Application Number:
  US11/173,713
• Publication Number:
  US 20050283229A1
• Time in Patent Office: 4,772 Days
• Field of Search: 623 115, 623 138, 623 142, 623 145, 623 146, 623 2375, 506 115, 506 138
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2230/0013 Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2250/0019 differing in hardness, e.g. Vickers, Shore, Brinell
• CPC Class Codes: A61F 2250/003 differing in adsorbability or resorbability, i.e. in adsorption or resorption time
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body

Abstract

An implantable medical device, such as a stent, with a coating region for controlling erosion of the substrate region is disclosed.

Claims

1. A stent comprising:

at least one bioerodible metal strut; and

a coating coated around and contacting the at least one bioerodible metal strut, the coating comprising a bioabsorbable polymer and particles or fibers of a nonbioactive erodible metal pore-forming agent dispersed or mixed within the bioabsorbable polymer;

wherein the at least one bioerodible metal strut has a faster average erosion rate when exposed to bodily fluids than the coating when exposed to the bodily fluids;

wherein the at least one bioerodible metal strut is configured to start to erode when the coating is partially degraded after the stent is implanted in a vascular lumen; and

wherein the at least one bioerodible metal strut is configured to completely or almost completely erode before the coating is completely eroded.

2. The stent of claim 1, wherein the at least one bioerodible metal strut comprises magnesium, zinc, iron or a combination thereof.