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System and method for automated adjustment of cardiac resynchronization therapy control parameters

  • US 10,029,103 B2
  • Filed: 07/16/2012
  • Issued: 07/24/2018
  • Est. Priority Date: 07/14/2011
  • Status: Active Grant
First Claim
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1. A method for delivering cardiac resynchronization therapy to a patient'"'"'s heart with a cardiac rhythm management (CRM) device, the steps of the method comprising:

  • a) receiving intracardiac signals indicative of cardiac electrical activity in the patient'"'"'s heart, using electrodes in electrical communication with one of the CRM device and an external programmer, after delivery of electrical impulses to the heart;

    b)comparing the received cardiac electrical activity signals with a baseline cardiac electrical activity to characterize ventricular activation patterns using a QRS hieroglyphic framework, the baseline cardiac electrical activity acquired, using electrocardiograph surface leads, before the delivery of electrical impulses to the heart;

    c) determining an activation fusion response phenotype based on the comparison in step b), the activation fusion response phenotype corresponding with odds of increased ventricular activation wavefront fusion associated with improved ventricular pump function, the activation fusion response phenotype being differentiated into distinct mutually exclusive phenotypes, including a cancellation fusion response phenotype, an oblique fusion response phenotype, and a summation fusion response phenotype;

    d) setting one or more pacing control parameters based on the activation fusion response phenotype determined in step c) and the comparison in step (b); and

    e) delivering cardiac resynchronization therapy to the patient'"'"'s heart using the one or more pacing control parameters.

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