Biological state eliminating apparatus and method

• US 10,034,612 B2
• Filed: 12/22/2015
• Issued: 07/31/2018
• Est. Priority Date: 06/28/2013
• Status: Active Grant

• Current Assignee: Fatigue Science Laboratory Inc., Murata Manufacturing Co Limited
• Original Assignee: Fatigue Science Laboratory Inc., Murata Manufacturing Co Limited
• Inventors: Shimuta, Toru, Kuratsune, Hirohiko, Watanabe, Yasuyoshi
• Primary Examiner(s): MALAMUD, DEBORAH LESLIE
• Application Number:
  US14/978,502
• Publication Number:
  US 20160106320A1
• Time in Patent Office: 952 Days
• CPC Class Codes: A61B 2560/0431 Portable apparatus, e.g. comprising a handle or case
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/165 Evaluating the state of mind, e.g. depression, anxiety
• CPC Class Codes: A61B 5/282 Holders for multiple electrodes for introduction into the body A61B5/287
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity

Abstract

A biological state estimating apparatus includes a pair of electrocardiographic electrodes, a photoplethysmographic sensor, and a controller that includes a peak detecting section, a pulse transmission time measuring section, a correlation information storing section, and a biological state estimating section. The electrocardiographic electrodes detect an electrocardiogram signal and the photoplethysmographic sensor, which has light-emitting and light-receiving elements, detects a photoplethysmogram signal. The controller detects peaks of the electrocardiogram and photoplethysmogram signals and determines a pulse transmission time from the time difference between the respective peaks of the photoplethysmogram and the electrocardiogram signal. Memory stores information determined in advance based on the relationship between pulse transmission time and biological state. The controller further estimates the biological state of the user on the basis of the pulse transmission time, and the correlation information stored in the correlation information storing section.

Claims

1. A biological state estimating apparatus comprising:

a pair of non-invasive electrocardiographic electrodes configured to detect an electrocardiogram signal of a user without implanting the electrocardiographic electrodes in the user;

a non-invasive photoplethysmographic sensor configured to detect a photoplethysmogram signal, the non-invasive photoplethysmographic sensor having a light-emitting element and a light-receiving element;

electronic memory storing a plurality of sleep state correlation information that indicates a relationship between pulse transmission times and a state of sleep and that is predetermined based on a relationship between pulse transmission times before sleep, pulse transmission times after sleep, and a state of sleep; and

a controller configured to;

detect a peak of the electrocardiogram signal,

detect a peak of the photoplethysmogram signal,

calculate a pulse transmission time based on a time difference between the respective peaks of the photoplethysmogram signal and the electrocardiogram signal, and

estimate a state of sleep of the user based on a calculated pulse transmission time before sleep of the user, a calculated pulse transmission time after sleep of the user, and the plurality of sleep state correlation information stored in the electronic memory.

2. The biological state estimating apparatus according to claim 1,

wherein the controller is further configured to calculate an amount of variation in a calculated pulse transmission time before and after a predetermined action that places a load on a heart,

wherein the electronic memory further stores blood vessel distensibility correlation information that is predetermined based on a relationship between an amount of variation in pulse transmission time before and after the predetermined action and blood vessel distensibility, and

wherein the controller is further configured to estimate blood vessel distensibility of the user based on an amount of variation in a calculated pulse transmission time and the blood vessel distensibility correlation information.

3. The biological state estimating apparatus according to claim 1,

wherein the non-invasive electrocardiographic electrodes are attached to a housing at a location on the housing such that when the user grasps the housing with left and right hands, one of the left and right hands is in contact with a first of the electrocardiographic electrodes and another of the left and right hands is in contact with a second of the electrocardiographic electrodes, and

wherein the non-invasive photoplethysmographic sensor is attached to the housing at a location such that when the user grasps the housing with the left and right hands, the non-invasive photoplethysmographic sensor is in contact with one of the left and right hands of the user.

4. The biological state estimating apparatus according to claim 1,

wherein one of the non-invasive electrocardiographic electrodes is configured to be in contact with the user between a fingertip and a shoulder on one arm of the user, another of the non-invasive electrocardiographic electrodes is configured to be in contact with the user between a fingertip and a shoulder on another arm of the user, and a wiring cable connected to the non-invasive electrocardiographic electrodes is configured to be routed along a surface of a body of the user, and

wherein the non-invasive photoplethysmographic sensor is configured to be in contact with between the fingertip and the shoulder on one of the one arm and the another arm of the user.

5. The biological state estimating apparatus according to claim 1, wherein the electronic memory stores the plurality of sleep state correlation information indicative of the relationship between pulse transmission times and the state of sleep, individually for at least one of each age and each sex.

6. The biological state estimating apparatus according to claim 1, wherein the controller automatically starts estimating the state of sleep of the user upon satisfaction of at least one condition including detecting contact of the user with the biological state estimating apparatus, acquiring the electrocardiogram signal and the photoplethysmogram signal over a predetermined number of beats, and payment of a consideration.

7. The biological state estimating apparatus according to claim 6, wherein the controller is further configured to automatically stop estimating the state of sleep of the user upon satisfaction of at least one condition including acquisition of the electrocardiogram signal and the photoplethysmogram signal over a predetermined number of beats, and lapsing of a predetermined time after the estimating of the state of sleep is started.

8. The biological state estimating apparatus according to claim 7, further comprising a presenting unit configured to present information relating to the estimate state of sleep of the user by at least one of guidance by voice and an image, at a time of automatically starting the estimating of the state of sleep and automatically ending the estimating of the state of sleep.

9. The biological state estimating apparatus according to claim 1, wherein the electronic memory stores the plurality of sleep state correlation information in a table of biological information that is predetermined based on the relationship between the pulse transmission times and the state of sleep.

10. A biological state estimating apparatus comprising:

a pair of non-invasive electrocardiographic electrodes configured to detect an electrocardiogram signal of a user without implanting the electrocardiographic electrodes in the user;

a non-invasive photoplethysmographic sensor configured to detect a photoplethysmogram signal, the non-invasive photoplethysmographic sensor having a light-emitting element and a light-receiving element;

electronic memory storing a plurality of sleep state correlation information that indicates a relationship between pulse transmission times and a state of sleep and that is predetermined based on a relationship between a variation of pulse transmission times during sleep and a state of sleep; and

a controller configured to;

detect a peak of the electrocardiogram signal,

detect a peak of the photoplethysmogram signal,

calculate a pulse transmission time based on a time difference between the respective peaks of the photoplethysmogram signal and the electrocardiogram signal, and

estimate a state of sleep of the user based on a variation of the calculated pulse transmission time during sleep of the user and the sleep state correlation information stored in the electronic memory.

11. A method for estimating a biological state of a user, the method comprising:

detecting an electrocardiogram signal of the user by a pair of non-invasive electrocardiographic electrodes without implanting the electrocardiographic electrodes in the user;

detecting a photoplethysmogram signal of the user by a non-invasive photoplethysmographic sensor having a light-emitting element and a light-receiving element;

storing, by electronic memory, a plurality of sleep state correlation information that indicates a relationship between pulse transmission times and a state of sleep and that is predetermined based on a relationship between pulse transmission times before sleep, pulse transmission times after sleep, and a state of sleep;

detecting a peak of the electrocardiogram signal;

detecting a peak of the photoplethysmogram signal;

calculating a pulse transmission time based on a time difference between the respective peaks of the photoplethysmogram signal and the electrocardiogram signal;

storing, by the electronic memory, the calculated pulse transmission time; and

estimating a state of sleep of the user based on a calculated pulse transmission time before sleep of the user, a calculated pulse transmission time after sleep of the user, and the plurality of sleep state correlation information stored in the electronic memory.

12. The method for estimating the biological state of the user according to claim 11, further comprising:

storing, by the electronic memory, a variation of the calculated pulse transmission time and the sleep state correlation information that is predetermined based on a relationship between variation of pulse transmission times during sleep and the state of sleep; and

estimating the state of sleep of the user based on a variation of a calculated pulse transmission time during the sleep of the user and the sleep state correlation information.

13. The method for estimating the biological state of the user according to claim 11, further comprising:

calculating an amount of variation in a calculated pulse transmission time before and after a predetermined action that places a load on a heart;

storing, by the electronic memory, blood vessel distensibility correlation information that is predetermined based on a relationship between an amount of variation in pulse transmission time before and after the predetermined action and blood vessel distensibility; and

estimating blood vessel distensibility of the user based on an amount of variation in a calculated pulse transmission time and the blood vessel distensibility correlation information.

14. The method for estimating the biological state of the user according to claim 11, further comprising storing, by the electronic memory, the plurality of sleep state correlation information indicative of the relationship between pulse transmission times and state of sleep, individually for at least one of each age and each sex.

15. The method for estimating the biological state of the user according to claim 11, further comprising automatically starting estimating the state of sleep of the user upon satisfaction of at least one condition including detecting contact of the user with at least one of the non-invasive electrocardiographic electrodes and the non-invasive photoplethysmographic sensor, acquiring the electrocardiogram signal and the photoplethysmogram signal over a predetermined number of beats, and payment of a consideration.