Rate-adaptive heart stimulator and activity sensor

• US 10,035,022 B2
• Filed: 06/01/2016
• Issued: 07/31/2018
• Est. Priority Date: 06/09/2015
• Status: Active Grant

• Current Assignee: Biotronik SE & Company KG
• Original Assignee: Biotronik SE & Company KG
• Inventors: Busch, Ulrich, Neumann, Andreas
• Primary Examiner(s): Fairchild, Mallika D
• Application Number:
  US15/170,895
• Publication Number:
  US 20160361548A1
• Time in Patent Office: 790 Days
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 5/02444 Details of sensor A61B5/02427 takes precedence
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/29 for permanent or long-term implantation
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/6869 Heart
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371
• CPC Class Codes: A61N 1/3704 Circuits specially adapted therefor, e.g. for sensitivity control
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Embodiments include a leadless implantable heart stimulator (that includes an acceleration sensor, wherein the acceleration sensor delivers an acceleration signal as an output signal. The acceleration sensor is connected to an activity determination unit. The activity determination unit generates an activity signal from the acceleration signal wherein the activity determination unit at least partially subtracts a component of the acceleration signal from the acceleration signal that represents an intrinsic heart movement.

Claims

1. A leadless implantable heart stimulator comprising:

an acceleration sensor that delivers an acceleration signal as an output signal, wherein the acceleration sensor is configured to record intrinsic heart movements and body movements, wherein the acceleration signal comprises

a first component caused by an intrinsic heart movement of said intrinsic heart movements, and,

a second component caused by a body movement of said body movements, and,

an activity determination unit,

wherein the acceleration sensor is connected to the activity determination unit,

wherein the acceleration signal is a signed acceleration signal,

wherein the activity determination unit is configured to integrate the signed acceleration signal over a predefined period of time to form an activity signal, and,

a control unit and a stimulation unit connected to the control unit,

wherein the control unit is connected to the activity determination unit,

wherein the control unit is configured to control the stimulation unit based on a stimulation rate,

wherein the stimulation unit

comprises a stimulation pulse generator and a stimulation electrode, and

provides stimulation pulses based on the stimulation rate, and,

wherein the stimulation rate is dependent on the activity signal.

2. The heart stimulator as claimed in claim 1, wherein the activity determination unit is further configured to form the activity signal over a cardiac cycle.

3. The heart stimulator as claimed in claim 1, wherein the control unit is connected to the activity determination unit and is configured to detect rest phases.

4. The heart stimulator as claimed in claim 1, further comprising at least one sensing unit and at least one electrode, wherein the at least one sensing unit is connected to the at least one electrode and is configured to record electrical potential curves via the at least one electrode as an electrocardiogram (ECG) signal and to detect signal features of signal characteristics of the ECG signal that correspond to intrinsic heart actions.

5. An activity detection module comprising:

an acceleration sensor that delivers an acceleration signal as an output signal, wherein the acceleration sensor is configured to record intrinsic heart movements and body movements, wherein the acceleration signal comprises

a first component caused by an intrinsic heart movement of said intrinsic heart movements, and,

a second component caused by a body movement of said body movements; and

,

an activity determination unit connected to the acceleration sensor,

wherein said acceleration signal is a signed acceleration signal,

wherein the activity determination unit is further configured to integrate the signed acceleration signal over a predefined period of time to form an activity signal, and,

a control unit and a stimulation unit connected to the control unit,

wherein the control unit is connected to the activity determination unit,

wherein the control unit is configured to control the stimulation unit based on a stimulation rate,

wherein the stimulation unit

comprises a stimulation pulse generator and a stimulation electrode, and

provides stimulation pulses based on the stimulation rate, and,

wherein the stimulation rate is dependent on the activity signal.

6. A method of forming an activity signal representing physical activity, comprising:

recording an acceleration signal using an acceleration sensor that delivers the acceleration signal as an output signal, wherein the acceleration sensor records intrinsic heart movements and body movements, wherein the acceleration signal comprises

a first component caused by an intrinsic heart movement of said intrinsic heart movements, and,

a second component caused by a body movement of said body movements,

integrating a signed acceleration signal over a predefined period of time to form an activity signal,

wherein said acceleration sensor is connected to an activity determination unit, and,

controlling a stimulation unit based on a stimulation rate using a control unit,

wherein the control unit is connected to the activity determination unit,

wherein the stimulation unit is connected to a control unit,

wherein the stimulation unit

comprises a stimulation pulse generator and a stimulation electrode, and

provides stimulation pulses based on the stimulation rate, and,

wherein the simulation rate is dependent on the activity signal.