Guanine analogs as telomerase substrates and telomere length affectors
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Abstract
This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are use in treating cancer and other cell proliferative diseases.
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34 Claims
- 1. A compound of formula (III):
- 16. A compound of formula (IV):
- 32. A method of treating breast or pancreatic cancer in an individual by administering an effective amount of a compound of formula (VI):
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