Anti-alpha V beta 6 antibodies and uses thereof
First Claim
Patent Images
1. An antibody or antigen-binding fragment thereof that specifically binds to α
- vβ
6, wherein the antibody or the antigen-binding fragment thereof comprises;
a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
1 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
9;
a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
3 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
9;
a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
5 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
9;
a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
7 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
9;
a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
50 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
9;
ora heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
52 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
9.
1 Assignment
0 Petitions
Accused Products
Abstract
Humanized antibodies and antibody fragments thereof that bind to αvβ6 are disclosed. Also disclosed are methods of using these antibodies and antibody fragments to treat or prevent αvβ6-mediated diseases such as fibrosis and cancer.
77 Citations
21 Claims
-
1. An antibody or antigen-binding fragment thereof that specifically binds to α
- vβ
6, wherein the antibody or the antigen-binding fragment thereof comprises;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
1 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
9;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
3 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
9;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
5 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
9;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
7 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
9;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
50 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
9;
ora heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
52 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
9. - View Dependent Claims (4, 7, 8, 9, 10, 11)
- vβ
-
2. An antibody or antigen-binding fragment thereof that specifically binds to α
- vβ
6, wherein the antibody or the antigen-binding fragment thereof comprises;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
1 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
11;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
3 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
11;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
5 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
11;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
7 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
11;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
50 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
11;
ora heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
52 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
11. - View Dependent Claims (5, 12, 14, 16, 18, 20)
- vβ
-
3. An antibody or antigen-binding fragment thereof that specifically binds to α
- vβ
6, wherein the antibody or the antigen-binding fragment thereof comprises;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
1 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
13;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
3 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
13;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
5 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
13;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
7 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
13;a heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
50 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
13;
ora heavy chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
52 and a light chain variable region that comprises the amino acid sequence set forth in SEQ ID NO;
13. - View Dependent Claims (6, 13, 15, 17, 19, 21)
- vβ
Specification